Soft tissue uptake of Tc99m-MDP in acute lymphoblastic leukemia

Extensive visceral calcification demonstrated on 99mTc-MDP bone scan in patient with carcinoma penis and hypercalcemia of malignancy

“…Causes of metastatic calcification include hyperparathyroidism, chronic renal disease, sarcoidosis, amyloidosis, myeloma, malignant hypercalcemia of lymphomas, and solid tumors. [ 1 2 3 4 5 6 7 8 9 10 ] The exact mechanism of these calcium depositions remains uncertain; however, most accepted mechanism is an increase in the production of ionized calcium (calcium-phosphate complex primarily). The precipitation of ionized calcium is mainly in the alkaline pH tissues: lung, kidneys, myocardium, liver, and stomach walls.…”

Diagnostics différentiels d’images d’hypofixations sur une scintigraphie du squelette: à propos d’un cas de leucémie aigue lymphoblastique

“…Cette dernière serait la conséquence d'une stimulation de la résorption osseuse en rapport avec une sécrétion de parathyroid hormone related protein par les cellules leucémiques [8]. L'hypercalcémie s'accompagne d'anomalies de fixation osseuse et/ou extra-osseuse très largement documentées [4, 9] mais absentes dans le cas présent. La topographie des anomalies scintigraphiques observées au cours des leucémies aigues est très variable et dépend de l’âge des patients.…”

Extraosseous myocardial uptake incidentally detected during bone scan: report of three cases and a systematic literature review of extraosseous uptake

“…Soft tissues are other potential sites for extraosseous uptake and have been reported to be correlated to conditions like amyloidosis [35], alterations in calcium metabolism [36,37], metastases [38] and multiple myeloma [39][40][41].…”

“…Extraosseous uptakes of 99mTc-labelled phosphates involving other organs are reported in patients with leukemia [41][42][43][44], parathyroid carcinoma [45], parathyroid adenoma [46], renal failure [38,47,48], lymphomas [49][50][51], multiple myeloma [52,53], Waldenstrom macroglobulinemia [12,54], hematological disorders [55][56][57][58][59][60], tumors [61][62][63][64][65][66][67][68][69], calcinosis [70,71] and vasculitis [72].…”