Software Tools for NMR Metabolomics

O’Sullivan, Aifric; Avizonis, Daina; German, J. Bruce; Slupsky, Carolyn M.

doi:10.1002/9780470034590.emrstm1232

Cited by 4 publications

(1 citation statement)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Once the metabolomics data are collected with quality control measures in place, the third step as shown in Figure 1 is bioinformatics and data analysis. First, the data is processed using vendor software or specialized bioinformatics software for analyzing metabolomics data [ 51 , 52 , 53 ]. After the metabolomics data are processed and normalized, they can be statistically analyzed.…”

Section: Metabolomics Proceduresmentioning

confidence: 99%

A Review of Applications of Metabolomics in Cancer

2013

View full text Add to dashboard Cite

Cancer is a devastating disease that alters the metabolism of a cell and the surrounding milieu. Metabolomics is a growing and powerful technology capable of detecting hundreds to thousands of metabolites in tissues and biofluids. The recent advances in metabolomics technologies have enabled a deeper investigation into the metabolism of cancer and a better understanding of how cancer cells use glycolysis, known as the “Warburg effect,” advantageously to produce the amino acids, nucleotides and lipids necessary for tumor proliferation and vascularization. Currently, metabolomics research is being used to discover diagnostic cancer biomarkers in the clinic, to better understand its complex heterogeneous nature, to discover pathways involved in cancer that could be used for new targets and to monitor metabolic biomarkers during therapeutic intervention. These metabolomics approaches may also provide clues to personalized cancer treatments by providing useful information to the clinician about the cancer patient’s response to medical interventions.

show abstract

Section: Metabolomics Proceduresmentioning

confidence: 99%