Sol-Gel Derived Tertiary Bioactive Glass–Ceramic Nanorods Prepared via Hydrothermal Process and Their Composites with Poly(Vinylpyrrolidone-Co-Vinylsilane)

Abstract

Bioactive glass (BG) nanoparticles have wide applications in bone repair due to their bone-bonding and biodegradable nature. In this work, nanometric rod-shaped ternary SiO2-CaO-P2O5 bioactive glass particles were prepared through sol-gel chemistry followed by a base-induced hydrothermal process at 130 °C and 170 °C for various times up to 36 h. This facile, low-temperature and surfactant-free hydrothermal process has shown to be capable of producing uniform nanorods and nanowires. One-dimensional growth of nanorods and the characteristics of siloxane bridging networks were dependent on the hydrothermal temperature and time. Hardened bioactive composites were prepared from BG nanorods and cryo-milled poly(vinylpyrrolidone-co-triethoxyvinylsilane) in the presence of ammonium phosphate as potential bone graft biomaterials. Covalent crosslinking has been observed between the organic and inorganic components within these composites. The ultimate compressive strength and modulus values increased with increasing co-polymer content, reaching 27 MPa and 500 MPa respectively with 30% co-polymer incorporation. The materials degraded in a controlled non-linear manner when incubated in phosphate-buffered saline from 6 h to 14 days. Fibroblast cell attachment and spreading on the composite were not as good as the positive control surfaces and suggested that they may require protein coating in order to promote favorable cell interactions.

Self-crystallisation, an unexpected property of 45S5 Bioglass®

“…It is worth noting that similar clusters of acicular crystals were reported by Mondal et al 12 for a sol-gel derived bioactive glass with a composition of 70SiO 2 , 26CaO and 4P 2 O 5 (mol%), after a hydrothermal process (36h at 170C) (Figure S3, ESI). Those acicular crystals had a size of 2-10μm and were identified as hydroxyapatite.…”

Sea Cucumber‐Inspired Aerogel for Ultrafast Hemostasis of Open Fracture

“…[ 34 ] We compared the degradation characteristics of GCG‐4H and GCG based on previous research to verify the effect of inorganic materials (Figure S8, Supporting Information). [ 35 ] Nevertheless, there are also literatures showing that the addition of inorganic materials will cause greater damage to the quality of materials. [ 36 ] This may be due to the decomposition of organic materials leading to the release of more inorganic materials doped in the materials.…”

Tissue engineering and regenerative therapeutics: The nexus of chemical engineering and translational medicine

“…[14,72] The combination of organic and inorganic biomaterials to design composites has been used for imparting specific properties. [73][74][75] This offers greater advantages by improving the mechanical and biological properties and providing a more basic or neutral pH environment [11] for the degradation products. With appropriate biomaterials synthesis and modification, the design and fabrication of scaffolds is required to develop an environment in which the damaged tissues can be repaired and regenerated.…”