Solid lipid nanoparticles as an efficient drug delivery system of olmesartan medoxomil for the treatment of hypertension

Solid Lipid Nanoparticles for Drug Delivery: Pharmacological and Biopharmaceutical Aspects

“…Therefore, the preparation of these dispersions necessarily implies transferring energy to the system, in order to generate very small particles, with very high specific surface area (Troy, 2000). Regardless the details of each synthesis method, they all share the common feature of an energy-providing step, under the form of ultrasonic waves [probe-type sonication (Haque et al, 2018;Pandya et al, 2018;Scioli Montoto et al, 2018) or ultrasonic bath (Rajpoot and Jain, 2018;Rosière et al, 2018;Chirio et al, 2019), high pressures (de Jesus et al, 2013;Küçüktürkmen and Bozkır, 2018;Wang et al, 2018), high speed homogenization (Nakhlband et al, 2018;Sathya et al, 2018;Youssef et al, 2018), or even microwaves (Shah et al, 2016a)]. The comparative performance of the two most commonly applied methods for lipid NPs preparation, hot homogenization and high pressure homogenization, was evaluated in the first studies within the field (Schwarz et al, 1994).…”

“…As said before, decreasing the amount of lipid incorporated into the formulation frequently helps to reduce particle size, but has a negative effect on the entrapment efficiency (Kurakula et al, 2016;Talluri et al, 2017;Ahmad et al, 2019). Simultaneous optimization of both responses as a function of the formulation components and/or process operational variables allows to find the optimum compromise solution as well as other possible approaches, such as increasing the energy (frequency, speed) during the synthesis to decrease the particle size without sacrificing entrapment efficiency (Nooli et al, 2017;Dara et al, 2019;Khatri et al, 2019;Patel et al, 2019a), or decreasing the surfactant/lipid ratio (Bhalekar et al, 2017;Pandya et al, 2018;Ahmad et al, 2019).…”

Green Nanotechnology-Driven Drug Delivery Assemblies

“…Olmesartan medoxomil (a BCS class II drug)-loaded SLNs were prepared by a hot homogenization process to increase their oral bioavailability. The in vivo pharmakinetic studies revealed that the olmesartan medoxomil-loaded SLNs showed a higher C max of 1610 mg/mL and increased the relative bioavailability by almost 2.3-fold than the marketed formulation . Mehrad and co-workers reported SLNs of size <220 nm with spherical morphology using microemulsification method.…”

<p>Recent Advances in Oral Nano-Antibiotics for Bacterial Infection Therapy</p>

“…Solid lipid nanoparticles (SLNs) were first designed in the 1990s by Schwarzetal et al 91 These are composed of medium-or long-chain lipids eg anisodylglycerol, tripalmitin, and stearic acid that have high melting points and are electrically neutral, SLNs are shell-core structured with a particle size between 10 and 1000 nm. 92,93 SLNs are particularly effective in avoiding the first-pass metabolism and increasing the intestinal lymphatic transport via paracellular and transcellular pathways of enterocytes, and endocytosis of phagocytic cells. 94,95 In addition to the solid lipids, surfactants such as Tween-80, PVA and Pluronic F-68 are also used in SLNs.…”