Solid lipid nanoparticles for drug delivery

Harms, Meike; Müller‐Goymann, Christel C.

doi:10.1016/s1773-2247(11)50008-5

Cited by 49 publications

(28 citation statements)

References 117 publications

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“…Indeed production of non-viral gene delivery vehicles may be less expensive than viralbased methods which always risk including wild-type virus in the Similar status exists in the employment of other cationic polymeric vectors, which are non-degradable and might lead to consequent risk of accumulation in the body (Dai et al, 2011). One approach to solve this challenge is through the use of cationic solid lipid nanoparticles (SLN) that have established themselves during the past decades as stable, reliable and easy to produce vectors (Harms and Müller-Goymann, 2011). SLN advantages over other existing transfection vectors include safety of the substances they are made, good storage stability, possibility of lyophilization and a large degree of flexibility in the design of their properties.…”

Section: Introductionmentioning

confidence: 99%

Design flexibility influencing the in vitro behavior of cationic SLN as a nonviral gene vector

Vighi

Montanari

Hanuskova

et al. 2013

International Journal of Pharmaceutics

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Section: Introductionmentioning

confidence: 99%

Design flexibility influencing the in vitro behavior of cationic SLN as a nonviral gene vector

Vighi

Montanari

Hanuskova

et al. 2013

International Journal of Pharmaceutics

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“…Such systems form an intravenous depot. Further studies with different drugs such as idarubicin, doxorubicin, tobramycin, clozapine or temozolomide also showed a sustained release as described in a review paper by Harms and Müller-Goymann [81].…”

Section: Lipid Nanoparticles For Parenteral Drug Deliverymentioning

confidence: 75%

Lipid Nanoparticulate Drug Delivery Systems: A Revolution in Dosage Form Design and Development

Attama¹,

Momoh²,

Builders³

2012

Recent Advances in Novel Drug Carrier Systems

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“…Measurement of zeta potential: Zetasizer (Malvern Instruments) was used to measure Zeta Potential. 18 Samples were prepared for analyzing zeta potential by diluting 1ml of the SLN dispersion with 10ml Millipore water.…”

Section: Characterization Of Solid Lipid Nanoparticlesmentioning

confidence: 99%

Zaltoprofen Loaded Solid Lipid Nanoparticles for Topical Delivery: Formulation Design, In Vitro and Ex Vivo Evaluation

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2017

MOJBB

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12Nanoemulsion gel 13 and as drug loaded biopolymeric nanoparticles.14 All these results suggest that zaltoprofen possesses novel antiinflammatory mechanism, which inhibits β 2 -type BK receptor function in nerve endings and shows potential to be delivered using novel drug delivery systems. Materials and methods MaterialsZaltoprofen API was received as a gift sample from IPCA Laboratories, Mumbai. Glycerol Monostearate and Tween 80 were purchased from Loba Chemie, Poloxamer 188 was obtained from BASF, Methanol and Acetonitrile (HPLC grade) were purchased from SRL Fine chemicals, Carbopol 940, Triethanolamine, Methyl paraben, Propyl paraben were purchased from SD Chemicals. Millipore water was used throughout the study. MOJ AbstractThe objective of present study is development and evaluation of solid lipid nanoparticles (SLNs) of Zaltoprofen (ZLT) for topical delivery to formulate topical formulation with prolonged effects. ZLT loaded SLNs (ZLT-SLN) were formulated using Taguchi design of Experiment and the effect of lipid ratio, surfactant ratio, stirring time and concentration of surfactant was studied on entrapment efficiency. The optimized formulation was spherical in shape with mean particle size distribution of 208nm and zeta potential of -25mV. They were characterized for structural changes using Differential Scanning Colorimetry and Fourier Transform Infrared Spectroscopy. Optimized nanoparticles were further incorporated in carbopol hydrogel and characterized for pH, homogeneity, viscosity and spreadability. In vitro and Ex vivo studies were carried out for ZLT-SLN loaded carbopol gel and compared against ZLT-SLN suspension. ZLT-SLN suspension followed Higuchi cube root model whereas ZLT-SLN loaded gel followed Korsemeyer Peppas model in in vitro as well as ex vivo studies which may be due to increase in viscosity. SLN loaded gel showed sustained release as compared to plain drug loaded hydrogel confirming that SLN are efficient to encapsulate ZLT and effective for sustained release of drug. Keywords Screening of lipids and solventsThe aim of this study was to develop a solid lipid nanoparticle for topical formulation. Considering solubility of drug in lipids as one of the most important criteria, lipid and solvents were selected cautiously. The solubility of drug in lipid phase can affect the ability of the nanosuspension to maintain the drug in a solubilized form which is important in maintaining stability. The solubility of ZLT in various lipids was determined by adding an excess amount of drug in 100mg of selected lipid (Stearic acid, Glycerol monostearate, Compritol 888 ATO, Precirol 888 ATO and Lipoid S-75), in 10mL capacity beaker using a magnetic stirrer. Similarly different volatile organic solvents (Acetone, Dichloromethane, Ethanol and Methanol) exhibiting good solubility for zaltoprofen were screened for its ability to solubilize the lipid. Preparation of solid lipid nanoparticlesBased on the solubility studies of drug, Glycerol monostearate 15 was selected as the lipid phase and Methanol a...

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Solid lipid nanoparticles for drug delivery

Cited by 49 publications

References 117 publications

Design flexibility influencing the in vitro behavior of cationic SLN as a nonviral gene vector

Design flexibility influencing the in vitro behavior of cationic SLN as a nonviral gene vector

Lipid Nanoparticulate Drug Delivery Systems: A Revolution in Dosage Form Design and Development

Zaltoprofen Loaded Solid Lipid Nanoparticles for Topical Delivery: Formulation Design, In Vitro and Ex Vivo Evaluation

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