Solid lipid nanoparticles of a water soluble drug, ciprofloxacin hydrochloride

Abstract

The aim of this study was to understand and investigate the relationship between experimental factors and their responses in the preparation of ciprofloxacin hydrochloride based solid lipid nanoparticles. A quadratic relationship was studied by developing central composite rotatable design. Amount of lipid and drug, stirring speed and stirring time were selected as experimental factors while particle size, zeta potential and drug entrapment were used as responses. Prior to the experimental design, a qualitative prescreening study was performed to check the effect of various solid lipids and their combinations. Results showed that changing the amount of lipid, stirring speed and stirring time had a noticeable influence on the entrapment efficiencies and particle size of the prepared solid lipid nanoparticles. The particle size of a solid lipid nanoparticle was in the range of 159-246 nm and drug encapsulation efficiencies were marginally improved by choosing a binary mixture of physically incompatible solid lipids. Release of ciprofloxacin hydrochloride from solid lipid nanoparticle was considerably slow, and it shows Higuchi matrix model as the best fitted model. Study of solid lipid nanoparticle suggested that the lipid based carrier system could potentially be exploited as a delivery system with improved drug entrapment efficiency and controlled drug release for water soluble actives.

Influence of Various Process Variables and Formulation Excipients on the Engineering of Sertaconazole Solid Lipid Nanoparticles

“…The stirring rate of 2000 rpm, 3000 rpm and 4000 rpm (G1, G2 and G3) for 1 h was maintained and then APS and PDI were observed. 2.5.2 Influence of stirring time [14] Stirring time was optimized for 1 hr, 1.5 hr and 2 hr (H1, H2 and H3). The formulations were evaluated for APS and PDI.…”

Solid Lipid Nanoparticles: The Efficiency Carrier for Topical Delivery of Hydrophilic Drugs

“…[8] SLN is found to be a most promising carrier for hydrophobic drugs because of its high compatibility and easy incorporation efficiency. However, SLN as a carrier for hydrophilic water soluble molecule is remained a subject of an exhaustive research and discussion due to its incompatibility with hydrophilic molecule.…”

“…Insulin: A high EE% (89%) was revealed and mean particle size in the range of 418 ± 39 nm. [39] Ciprofloxacin Solvent diffusion method…”

Alginate-chitosan Coated Lecithin Core Shell Nanoparticles for Curcumin: Effect of Surface Charge on Release Properties and Biological Activities

“…The cell viability of the samples was studied by means of a colorimetric microculture assay (MTT) on HEK cell lines 20 . 1×104 cells/well were seeded in 100 μl DMEM, supplemented with 10% FBS in each well of 96-well microculture plates and incubated for 24 h at 37 °C in a CO 2 incubator.…”