Solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs): recent advances in drug delivery

Yoon, Goo; Park, Jin Woo; Yoon, In‐Soo

doi:10.1007/s40005-013-0087-y

Cited by 177 publications

(91 citation statements)

References 82 publications

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“…Notwithstanding the findings reported by other authors [8][9][10], in this study no large differences have been evidenced between NLC and SLN in terms of fluorescence loading and stability, at least for the composition of NLC and SLN tested in the current study. Therefore, this manuscript has demonstrated that NLC do not show any major advantage compared to SLN.…”

Section: Discussioncontrasting

confidence: 64%

Production, Physico-Chemical Characterization and Biodistribution Studies of Lipid Nanoparticles

Esposito¹

2015

J Nanomed Nanotechnol

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This study describes the preparation, characterization, in vitro uptake and in vivo biodistribution in mice of solid lipid nanoparticles and nanostructured lipid carriers. Biodistribution of solid lipid nanoparticles treated by polysorbate 80 was evaluated by fluorescent luminescent imaging after intraperitoneal administration in mice. The in vivo images indicate that nanoparticles were able to reach the brain, even if they prevalently accumulated in liver and spleen.

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Section: Discussioncontrasting

confidence: 64%

Production, Physico-Chemical Characterization and Biodistribution Studies of Lipid Nanoparticles

Esposito¹

2015

J Nanomed Nanotechnol

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“…22 Lipid nanoparticles possess many advantages, including biocompatibility, rapid cellular uptake, and potential for large-scale production. 23,24 In this respect, we selected a cationic lipid 1,2-dioleoyl-3-trimethylammonium-propane (DOTAP) to formulate solid lipid nanoparticles (SLN) for miRNA delivery. Nanostructured lipid carriers (NLC) consisting of solid and liquid lipids are a new generation of SLN.…”

Section: Liu Et Almentioning

confidence: 99%

MicroRNA-200c delivered by solid lipid nanoparticles enhances the effect of paclitaxel on breast cancer stem cell

Li¹,

Meng²,

Yuan³

et al. 2016

IJN

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“…These spatially different lipids do not form a highly ordered crystalline arrangement and thus provide more space for accommodating the encapsulated drugs. 19,20 NLCs topically applied to the skin can also alter the drug penetration flux, provide drug deposition and localization, 21 and even selectively permeate the stratum corneum (SC) by attaching themselves to the skin surface. In this way, adhesiveness and hydration are improved, and even lipid exchange between the lipid-based colloid carriers and the outermost layers of SC can be achieved.…”

Section: Introductionmentioning

confidence: 99%

Capsaicin-loaded nanolipoidal carriers for topical application: design, characterization, and in vitro/in vivo evaluation

Wang¹,

Gao²,

Niu³

et al. 2017

IJN

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Capsaicin has been used in clinical applications for the treatment of pain disorders and inflammatory diseases. Given the strong pungency and high oil/water partition coefficient of capsaicin, capsaicin-loaded nanolipoidal carriers (NLCs) were designed to increase permeation and achieve the analgesic, anti-inflammatory effect with lower skin irritation. Capsaicin-loaded NLCs were prepared and later optimized by the Box–Behnken design. The physicochemical characterizations, morphology, and encapsulation of the capsaicin-loaded NLCs were subsequently confirmed. Capsaicin-loaded NLCs and capsaicin-loaded NLCs gel exhibited sustained release and no cytotoxicity properties. Also, they could significantly enhance the penetration amount, permeation flux, and skin retention amounts of capsaicin due to the application of NLCs. To study the topical permeation mechanism of capsaicin, 3,3′-dioctadecyloxacarbocyanine perchlorate (Dio) was used as a fluorescent dye. Dio-loaded NLCs and Dio-loaded NLCs gel could effectively deliver Dio up to a skin depth of 260 and 210 μm, respectively, primarily through the appendage route on the basis of version skin sections compared with Dio solution, which only delivered Dio up to 150 μm. In vivo therapeutic experiments demonstrated that capsaicin-loaded NLCs and capsaicin-loaded NLCs gel could improve the pain threshold in a dose-dependent manner and inhibit inflammation, primarily by reducing the prostaglandin E2 levels in the tissue compared with capsaicin cream and capsaicin solution. Meanwhile, skin irritation was reduced, indicating that application of NLCs could decrease the irritation caused by capsaicin. Overall, NLCs may be a potential carrier for topical delivery of capsaicin for useful pain and inflammation therapy.

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Solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs): recent advances in drug delivery

Cited by 177 publications

References 82 publications

Production, Physico-Chemical Characterization and Biodistribution Studies of Lipid Nanoparticles

Production, Physico-Chemical Characterization and Biodistribution Studies of Lipid Nanoparticles

MicroRNA-200c delivered by solid lipid nanoparticles enhances the effect of paclitaxel on breast cancer stem cell

Capsaicin-loaded nanolipoidal carriers for topical application: design, characterization, and in vitro/in vivo evaluation

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