Slip boundary has an important influence on fluid flow, which is non-negligible in rock micro-fractures. In this paper, an improved pseudo-potential multi-relaxation-time (MRT) lattice Boltzmann method (LBM), which can achieve a large density ratio, is introduced to simulate the fluid flow in a micro-fracture. The model is tested to satisfy thermodynamic consistency and simulate Poiseuille flow in the case of large liquid-gas density ratio. The slip length is used as an index for evaluating the flow characteristics, and the effects of wall wettability, micro-fracture width, driving pressure and liquid-gas density ratio on the slip length are discussed. The results demonstrate that the slip length increases significantly with the increase of the wall contact angle in rock micro-fracture. And the liquid-gas density ratio has an important impact on the slip length, especially for the hydrophobic wall. Moreover, under the laminar flow regime the driving pressure and the micro-fracture width has little effect on the slip length.