Solid self-emulsifying phospholipid suspension (SSEPS) with diatom as a drug carrier

Milović, Mladen; Simović, Spomenka; Lošić, Dušan; Dashevskiy, Andriy; Ibrić, Svetlana

doi:10.1016/j.ejps.2014.07.010

Cited by 32 publications

(21 citation statements)

References 32 publications

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“…While the physical mixture procedure was more efficient, mixing with the ethanolic extract deemed faster. Both processes, however, showed prolonged longevity (Milovic et al, 2014). Diatom has also been used for transport of siRNA into tumor cells (Rea et al, 2014).…”

Section: Nanomedicine and Medical Applicationsmentioning

confidence: 99%

All New Faces of Diatoms: Potential Source of Nanomaterials and Beyond

et al. 2017

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Nature’s silicon marvel, the diatoms have lately astounded the scientific community with its intricate designs and lasting durability. Diatoms are a major group of phytoplanktons involved in the biogeochemical cycling of silica and are virtually inherent in every environment ranging from water to ice to soil. The usage of diatoms has proved prudently cost effective and its handling neither requires costly materials nor sophisticated instruments. Diatoms can easily be acquired from the environment, their culture requires ambient condition and does not involve any costly media or expensive instruments, besides, they can be transported in small quantities and proliferated to a desirable confluence from that scratch, thus are excellent cost effective industrial raw material. Naturally occurring diatom frustules are a source of nanomaterials. Their silica bio-shells have raised curiosity among nanotechnologists who hope that diatoms will facilitate tailoring minuscule structures which are beyond the capabilities of material scientists. Additionally, there is a colossal diversity in the dimensions of diatoms as the frustule shape differs from species to species; this provides a scope for the choice of a particular species of diatom to be tailored to an exacting requisite, thus paving the way to create desired three dimensional nanocomposites. The present article explores the use of diatoms in various arenas of science, may it be in nanotechnology, biotechnology, environmental science, biophysics or biochemistry and summarizes facets of diatom biology under one umbrella. Special emphasis has been given to biosilicification, biomineralization and use of diatoms as nanomaterials’, drug delivery vehicles, optical and immune-biosensors, filters, immunodiagnostics, aquaculture feeds, lab-on-a-chip, metabolites, and biofuels.

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Section: Nanomedicine and Medical Applicationsmentioning

confidence: 99%

All New Faces of Diatoms: Potential Source of Nanomaterials and Beyond

et al. 2017

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“…Además de mejorar los aspectos farmacocinéticos, estos BA-PEG mostraron una mejora significativa en lo concerniente a seguridad, obteniendo valores de su concentración de inhibición media (IC50) mayores y porcentaje de hemólisis menores en comparación con Tween 80, usado comúnmente en la industria farmacéutica [106], ratificando así el potencial de los BA-PEG como buenos candidatos como excipientes farmacéuticos. Asimismo, los fosfolípidos que tienen una mayor biocompatibilidad han sido empleados como cotensioactivos en diversas investigaciones sobre SEDDS logrando obtener una mayor estabilidad y capacidad de solubilización del sistema, ya que promueven la formación de micelas mezcladas permitiendo así la reducción en la concentración de los tensioactivos y sus efectos adversos [63,116].…”

Section: Tensioactivounclassified

Sistemas de entrega de fármacos autoemulsificables: una plataforma de desarrollo alternativa para la industria farmacéutica colombiana

Cueto

Ortega

Sotomayor

2019

Rev. Colomb. Cienc. Quím. Farm.

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Los grandes avances tecnológicos en la industria farmacéutica, que involucran el uso de la química combinatoria y el cribado de alto rendimiento, han conllevado al descubrimiento de muchas entidades químicas candidatas a fármacos que presentan baja solubilidad acuosa, debido a su elevada complejidad molecular, lo que hace difícil el desarrollo de productos con estas sustancias. Los sistemas de entrega de fármacos autoemulsificables (SEDDS) han generado un interés para el desarrollo farmacéutico porque son una alternativa efectiva para mejorar la biodisponibilidad de fármacos poco solubles en agua. Para describir el estado de conocimiento sobre estos sistemas se realizó una revisión sistemática en diferentes bases de datos sobre la literatura relacionada con los SEDDS a nivel nacional e internacional, logrando así describir los aspectos más relevantes sobre los SEDDS (tipos, composición, mecanismos para aumentar biodisponibilidad, caracterización, formulaciones). A pesar de las numerosas investigaciones realizadas durante los últimos años que muestran el potencial de los SEDDS para mejorar la biodisponibilidad de los fármacos poco solubles en agua, se pudo evidenciar que solo algunas sustancias activas han sido incluidas en estos sistemas y comercializadas exitosamente, esto debido a algunas limitaciones que indican la necesidad de un mayor entendimiento sobre estos sistemas.

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“…Principally, two steps of drug release from the frustules were observed: the first over 6 h was rapid due to the surface deposition of the drug, and the second was slow and sustained over two weeks with zero order kinetics ascribed to the release from the internal hallow structure. Zhang reported, for the first time, the application of diatom as a solid carrier for water insoluble carbamazepine drug (CBZ) applied in oral drug delivery system based on the self-emulsifying drug delivery system (SEDDS) [49]. Different solid samples of CBZ suspension in SEDDS, were prepared using two methods.…”

Section: Micro-nano Carriers For Delivery Of Therapeuticsmentioning

confidence: 99%

Diatoms Green Nanotechnology for Biosilica-Based Drug Delivery Systems

Terracciano¹,

Stefano²,

Rea³

2018

Preprint

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Diatom microalgae are the most outstanding natural source of porous silica. Diatom cell is enclosed in 3-D ordered nanopatterned silica cell wall, called frustule. The unique properties of diatoms frustule, including high specific surface area, thermal stability, biocompatibility, tailorable surface chemistry, make them really promising for biomedical applications. Moreover, diatoms are easy to cultivate in artificial environment and there is a huge availability of diatom frustules as fossil material (diatomite) in several areas of the world. For all these reasons, diatoms are an intriguing alternative to synthetic materials for the development of low-cost drug delivery systems. This review article focuses on the possible use of diatoms derived silica as drug carrier systems. The functionalization strategies of diatom micro-/nanoparticles for improving their biophysical properties, such as cellular internalization and drug loading/release kinetics, are described. In addition, the realization of hybrid diatom-based devices with advanced properties for theranostics and targeted or augmented drug delivery applications, are also discussed.

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Solid self-emulsifying phospholipid suspension (SSEPS) with diatom as a drug carrier

Cited by 32 publications

References 32 publications

All New Faces of Diatoms: Potential Source of Nanomaterials and Beyond

All New Faces of Diatoms: Potential Source of Nanomaterials and Beyond

Sistemas de entrega de fármacos autoemulsificables: una plataforma de desarrollo alternativa para la industria farmacéutica colombiana

Diatoms Green Nanotechnology for Biosilica-Based Drug Delivery Systems

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