Solid-State Characterization and Dissolution Properties of Meloxicam–Moringa Coagulant–PVP Ternary Solid Dispersions

Abstract

Abstract. The effect of ternary solid dispersions of poor water-soluble NSAID meloxicam with moringa coagulant (obtained by salt extraction of moringa seeds) and polyvinylpyrrolidone on the in vitro dissolution properties has been investigated. Binary (meloxicam-moringa and meloxicam-polyvinylpyrrolidone (PVP)) and ternary (meloxicam-moringa-PVP) systems were prepared by physical kneading and ball milling and characterized by Fourier transform infrared spectroscopy, differential scanning calorimetry, and X-ray diffractometry. The in vitro dissolution behavior of meloxicam from the different products was evaluated by means of United States Pharmacopeia type II dissolution apparatus. The results of solid-state studies indicated the presence of strong interactions between meloxicam, moringa, and PVP which were of totally amorphous nature. All ternary combinations were significantly more effective than the corresponding binary systems in improving the dissolution rate of meloxicam. The best performance in this respect was given by the ternary combination employing meloxicam-moringa-PVP ratio of [1:(3:1)] prepared by ball milling, with about six times increase in percent dissolution rate, whereas meloxicam-moringa (1:3) and meloxicam-PVP (1:4) prepared by ball milling improved dissolution of meloxicam by almost 3-and 2.5-folds, respectively. The achieved excellent dissolution enhancement of meloxicam in the ternary systems was attributed to the combined effects of impartation of hydrophilic characteristic by PVP, as well as to the synergistic interaction between moringa and PVP.

Enhanced dissolution and bioavailability of Nateglinide by microenvironmental pH-regulated ternary solid dispersion: in-vitro and in-vivo evaluation

“…Broadening of PL‐188 endotherm along with the complete absence of Na 2 CO 3 endotherm is an indicator of intermolecular interactions. Aforesaid findings can be supported with the absence of Na 2 CO 3 peaks in MeSD diffractogram, confirming the ternary interaction of NT, PL‐188 and alkalszer . Besides, single T g observed in MeSD formulation is an indicator of molecular level ternary dispersion of NT.…”

Effervescence Assisted Fusion Technique to Enhance the Solubility of Drugs

“…Binary or ternary solid dispersions have been reported to be more successful since they provide physical stability and prevents recrystallization of drug (4,(6)(7)(8)(9). Use of surfactant with carrier enhances the wettability and solubilization of the drug and also assists in drug release (10)(11)(12).…”

Biological, nutritional, and therapeutic significance of Moringa oleifera Lam

“…Cognis Laboratories Serobiol Ogiques group formulated Puricare TM and Purisoft TM, two dynamic ingredients based on natural peptides of MO seeds, which offer protection against pollution effects on hairs and skin (Shah et al, ). The salt extract of seeds has also been used with povidone (polyvinylpyrrolidone) to enhance solubility of the partially soluble Non‐Steroidal Anti‐Inflammatory Drugs (NSAIDS) (Noolkar, Jadhav, Bhende, & Killedar, ). A study conducted by Torondel, Opare, Brandberg, Cobb, and Cairncross () concluded the viability of dried and wet leaf powder as a hand‐washing item and indicated dimensions of inhibition of E. coli similar to a nonmedicated liquid soap because of saponin content.…”