Solid-state, triboelectrostatic and dissolution characteristics of spray-dried piroxicam-glucosamine solid dispersions

Abstract

Solid-state, triboelectrostatic and dissolution characteristics of spray-dried piroxicam-glucosamine solid dispersions, Colloids and Surfaces B: Biointerfaces http://dx.doi.org/10. 1016/j.colsurfb.2016.07.032 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. 4. GLU improved the handling of PXM as it significantly reduced its charge in all the spray dried formulations. Technique could be used to determine appropriate formulations that improve handling AbstractThis work explores the use of both spray drying and D-glucosamine HCl (GLU) as a hydrophilic carrier to improve the dissolution rate of piroxicam (PXM) whilst investigating the electrostatic charges associated with the spray drying process. Spray dried PXM:GLU solid dispersions were prepared and characterised (XRPD, DSC, SEM). Dissolution and triboelectric charging was also conducted. The results showed that the spray dried PXM alone, without GLU produced some PXM form II (DSC results) with no enhancement in solubility relative to that of the parent PXM.XRPD results also showed the spray drying process to decrease the crystallinity of GLU and solid dispersions produced. The presence of GLU improved the dissolution rate of PXM. Spray dried PXM: GLU at a ratio of 2:1 had the most improved dissolution. The spray drying process generally yielded PXM-GLU spherical particles of around 2.5 µm which may have contributed to the improved dissolution. PXM showed a higher tendency for charging in comparison to the carrier GLU (-3.8 versus 0.5 nC/g for untreated material and -7.5 versus 3.1 nC/g for spray dried materials). Spray dried PXM and spray dried GLU demonstrated higher charge densities than untreated PXM and untreated GLU, respectively. Regardless of PXM:GLU ratio, all spray dried PXM:GLU solid dispersions showed a negligible charge density (net-CMR: 0.1 -0.3 3 nC/g). Spray drying of PXM:GLU solid dispersions can be used to produce formulation powders with practically no charge and thereby improving handling as well as dissolution behaviour of PXM.

Direct imaging of the dissolution of salt forms of a carboxylic acid drug

“…Common methods used in overcoming the poor solubility of these APIs include particle size reduction, complexation, using additives in crystallization, cocrystals, liquisolid techniques and salt formation (Adebisi et al, 2016a;Adebisi et al, 2016b;Al-Hamidi et al, 2014, 2010a, 2010bAsare-Addo et al, 2015;Nokhodchi et al, 2005;Rabinow, 2004;Stahl et al, 2008).…”

Imaging of the Effect of Alcohol-Containing Media on the Performance of Hypromellose Hydrophilic Matrix Tablets: Comparison of Direct Compression and Regular Grades of Polymer

“…Regardless of charge sign, powders containing CR had a lower absolute net-CMR than those containing HPMC DC ( Figure 4 c,d). The addition of excipients as well as processing parameters have been reported to have an effect on the charging properties of APIs [ 26 , 28 , 29 , 32 , 33 , 49 ]. Plotting the flow rate of different samples under investigation against the net-CMR showed powder flowability to decrease with the increase in net-CMR ( Figure 4 e).…”

“…The experimental apparatus consists of a single non-contact electrostatic inductive sensor (probe), a charge amplifier unit, a national instrument (NI) data acquisition equipment and personal computer for data recording and processing. A sample of each powder was fed into the cylindrical sensor with the help of vibratory feeder and conveyed toward the sensor by gravity in a vertical direction [ 31 , 32 , 33 ]. Special care was taken by considering the adhesion property of particles with the wall of the sensor.…”

Formulation and optimization of quinoa starch nanoparticles: Quality by design approach for solubility enhancement of piroxicam

“…The drug piroxicam is a dynamic NSAID belongs to BCS-II is described as practically insoluble in water (0.023 mg/ml) and is widely employed in the treatment of acute and chronic musculoskeletal and joint disorders such as rheumatoid arthritis, osteoarthritis, ankylosing spondylitis ( Adebisi et al, 2016 , Gholivand et al, 2014 ) , is used as a model drug in this piece of research. The mode of action of NSAIDs includes the inhibition of the enzyme cyclooxygenase (COX) which is responsible for the cause of inflammation ( Legrand, 2004 ).…”