Solubility Determination and Thermodynamic Modeling of Amitriptyline Hydrochloride in 13 Pure Solvents at Temperatures of 283.15–323.15 K

Abstract

In this work, the solubility of amitriptyline hydrochloride (AMT) in 13 monosolvents was experimentally measured in the temperatures ranging from 283.15 to 323.15 K under atmospheric pressure with the aid of laser dynamic solubility monitor devices. The solubility as a function of temperature in different monosolvents was regressed using two activity coefficient models (Wilson and nonrandom two liquid (NRTL)) and three semiempirical equations (modified Apelblat, three-parameter Van’t Hoff, and λh), Based on the solubility data and the regression parameters of the Wilson model, the mixing thermodynamic properties (mixing Gibbs energy, mixing enthalpy, mixing entropy) as well as the activity coefficient and the reduced excess enthalpy at infinitesimal concentration were evaluated.

Determination and Modeling of Artesunate Solubility in 13 Pure Solvents at 283.15–323.15 K

“…The model parameters are listed in Tables –. For assessing the quality of the simulation results, relative average deviation (RAD) and root-mean-square deviation (RMSD), as defined in eqs and , were used. − RAD = 1 N ∑ i = 1 N | x i exp − x i cal x i exp | RMSD = ∑ i = 1 N false( x i exp − x i cal false) 2 N where x i exp is the experimental solubility, x i cal is the simulated solubility, and N is the number of experimental points.…”

“…The model parameters are listed in Tables –. For assessing the quality of the simulation results, relative average deviation (RAD) and root-mean-square deviation (RMSD), as defined in eqs and , were used. − where x i exp is the experimental solubility, x i cal is the simulated solubility, and N is the number of experimental points.…”

Solubility and Thermodynamic Properties of Clotrimazole in 16 Organic Solvents at Temperature of 283.15 to 323.15 K

“…The thermodynamic mixing properties of the real solution can be described by eqs and . normalΔ mix M = M normalE + normalΔ mix M id M = G , H 0.25em and 0.25em S where Δ mix M is the thermodynamic mixing property of the real solution; Δ mix M id is the thermodynamic mixing property of the ideal solution; and M E is the thermodynamic excess properties of the solution, which can be estimated using eqs −. , G normalE = R T ( x 1 ln ⁡ γ 1 + x 2 ln ⁡ γ 2 ) = prefix− R T [ x 1 ln false( x 1 + normalΛ 12 x 2 false) + x 2 ln false( x 2 + normalΛ 21 x 1 false) ] …”

Solubility Determination and Thermodynamic Modeling of Methanesulfonamide in 13 Pure Solvents at Temperatures of 283.15–323.15 K

“…The solubility of MSAM in the selected 13 pure solvents was measured in a jacketed crystallization flask of 100 mL, and the equilibrium of the dissolution was monitored in terms of a dynamic laser monitoring system comprising a laser generator, a photoelectric transformer, and a light intensity display. In order to verify the feasibility of the laser dynamic method, the solubility data of amitriptyline hydrochloride in n -propanol was first measured in this paper and then compared with those in ref . The comparison results are listed in Figure and Table , and the results show that this method is reliable.…”

“… a Standard uncertainties are u (T) = 0.05 K and u (p) = 0.5 kPa; relative standard uncertainty is u r ( x 1 ) = 0.05. x i and x i ref are the solubility data of amitriptyline hydrochloride in this work and in ref , respectively. …”