Solubility of Carvedilol in Ethanol + Propylene Glycol Mixtures at Various Temperatures

Abstract

Solubilities of carvedilol (CVD) in binary mixtures of (ethanol + propylene glycol (PG)) at 298.2, 303.2, 308.2, and 313.2 K are reported. The modified versions of the van't Hoff and Gibbs equations were used to calculate the thermodynamic properties (enthalpy (ΔH°), entropy (ΔS°), and Gibbs energy (ΔG°) standard changes of solutions) for CVD dissolved in (ethanol (1) + PG (2)) mixtures from the solubility data. The solubility data of CVD in (ethanol (1) + PG (2)) at different temperatures were correlated using different mathematical models, i.e., the Jouyban−Acree model, a combination of the Jouyban−Acree model with the van't Hoff model, and two modified versions of the Jouyban−Acree model. Solubility data of seven drugs in (ethanol (1) + PG (2)) at different temperatures were used to develop a quantitative structure−property relationship model for predicting solubility in solvent mixtures. In addition, enthalpy−entropy compensation using ΔH°vs ΔG°a nd ΔH°vs TΔS°which explains the mechanism of cosolvency at different temperatures was discussed.

Solubility measurement and modelling of ethyl 5-amino-4-cyano-3-(2-ethoxy-2-oxoethyl)-2-thiophenecarboxylate in four groups mixed solvents

“…In this work, three models widely used solid-liquid phase equilibrium are employed to correlate the solubility of ACET in binary solvent mixtures of (acetone + methanol), (acetone + ethanol), (acetone + 1-butanol) and (acetone + isopropanol) at various temperatures. These are the Jouyban-Acree model [21][22][23][24], a combination of the Jouyban-Acree model with the van't Hoff equation [25,26] and a combination of the modified Apelblat equation with the Jouyban-Acree model [27,28].…”

“…It is used to correlate the solute solubility against temperature at the same solvent composition and is shown as Eq. (4) [28,30].…”

Prediction of deferiprone solubility in some non-aqueous binary solvent mixtures at various temperatures

“…As described earlier, J i terms could be computed at 298.2 K, and then could be used to predict the solubility at other temperatures and the only required data for these predictions are the solubility of the solute in the mono-solvents at temperature of interest [26,[28][29][30]. To solve this limitation, it is possible to combine the trained versions of the Jouyban-Acree model using whole data points (from Table 2) and the van't Hoff equation taken from previous works [14,15] for providing predictive models for solubility prediction of DFP in EG + PG, EG + PEG 400, EG + NMP and EG + EtOH mixtures at various temperatures as: …”

Solubility determination and thermodynamic models for dehydroepiandrosterone acetate in mixed solvents of (ethyl acetate + methanol), (ethyl acetate + ethanol) and (ethyl acetate + isopropanol)

“…In the present work, three models are employed to correlate the solubility of DHEA acetate in binary solvent mixtures of (ethyl acetate + methanol), (ethyl acetate + ethanol) and (ethyl acetate + isopropanol) at various temperatures, which correspond to the Jouyban-Acree model [12,13], a combination of the JouybanAcree model with van't Hoff equation [14,15], and a combination of the Jouyban-Acree model with the modified Apelblat equation [12,14,15].…”