Soluble Tumor Necrosis Factor Receptor Prevents Post-pump Syndrome

Carney, David E.; Lutz, Charles J.; Picone, Anthony; Gatto, Louis A.; Schiller, Henry J.; Finck, Christine; Searles, Bruce; Paskanik, Andrew M.; Snyder, Kathy; Edwards, Carl K.; Nieman, Gary F.

doi:10.1006/jsre.1999.5576

Cited by 21 publications

(12 citation statements)

References 26 publications

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“…In a recent paper, it was documented that TNF-a might have a paracrine effect on neutrophil rather than an endocrine influence, and the increased tissue level of TNF-a, but not the circulating TNF-a concentration, correlated with neutrophil recruitment in the lungs [24]. In the present study, CLP caused significant increase in TNF-a expression in rat lung compared with sham group as expected.…”

supporting

confidence: 84%

Curcumin Protects Against Sepsis-Induced Acute Lung Injury in Rats

Xiao

Yang

Sun

et al. 2012

Journal of Surgical Research

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supporting

confidence: 84%

Curcumin Protects Against Sepsis-Induced Acute Lung Injury in Rats

Xiao

Yang

Sun

et al. 2012

Journal of Surgical Research

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“…Macrophages and monocytes have been to known to produce TNF-α, which initiates inflammatory reactions and involves in lung injury worsening [18]. A high level of TNF-α has been well known for the recruitment of neutrophils in the lung tissue [19]. Our experimental findings on cytokines have been found to be in agreement with the findings of an earlier report [20].…”

Section: Discussionsupporting

confidence: 90%

Mechanistic Evaluation of the Protective Effect of Carnosine on Acute Lung Injury in Sepsis Rats

Sun

Zhang

et al. 2017

Pharmacology

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This study analyzes the sepsis healing therapeutic potential of carnosine against experimentally sepsis-induced male albino rats. Carnosine in 2 different doses, 25 mg/kg and 50 mg/kg, were administered for 30 consecutive days. At the end of the treatment, lipid peroxidation, catalase, superoxide dismutase, glutathione peroxidase and myeloperoxidase activities were measured. Lungs weight and total protein content were determined in the bronchoalveolar fluid (BALF). Cytokines such as macrophage inhibitory factor (MIF), interleukin-8 (IL-8) and tumour necrosis factor-alpha (TNF-α) were determined in the BALF. In addition, the histopathological analysis was also carried out to understand the effect of carnosine in the cellular architecture. Carnosine treatment significantly renormalized the lipid peroxidation and other antioxidant enzymes. IL-β, TNF-α, and MIF were found to be reduced after carnosine treatment. After carnosine treatment, the intensity of sepsis was significantly reduced evidenced by histopathological analysis. In western blot analysis, carnosine treatment causes the upregulation of IκBα together with the downregulation of the expressions of p65 and p-IKKα/β (Ser 180/Ser 181).

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“…Moreover, it is noteworthy that down-regulation of the TNF-a level in pulmonary tissues was more significant than plasma in the curcumin-treated groups. In a recent paper, it was documented that TNF might have a paracrine effect on neutrophil rather than an endocrine influence, and the increased tissue level of TNF, but not the circulating TNF concentration, correlated with neutrophil recruitment in the lungs [36]. Based on these findings, we conclude that curcumin attenuates the inflammatory response, at least in part, via down-regulation of TNF-a in lung tissues.…”

Section: Discussionsupporting

confidence: 60%