Solvent Effect on the Enthalpy and Entropy of Activation for the Hydrolysis of Ethyl Cinnamate in Mixed Solvent System

Abstract

Abstract-

Studies of Solvent Effect of Aquo-Methanol Solvent System on Kinetics and Activation Parameters of Base Catalised Hydrolysis of Ethyl Cinnamate

“…Increase in ∆G* with simultaneous decrease in ∆H * and ∆S* values is only possible when extent (degree) of depletion in ∆S* value is greater than ∆H* values and from this, it may be inferred that alkali catalysed hydrolysis of ethyl cinnamate in water-methanol media act as Entropy inhibitor and Enthalpy stimulator solvent. Such inference have also recently been supported by recent view of Singh [11]. Barclay [12] and Butler relationship between Enthalpy and Entropy of Activation, which is as follows?…”

“…Study of solvent effect of protic and aprotic solvent on the reaction such as hydrolysis of ester and amide have been carried out by numbers of workers [1][2][3], but explanation put forward are not quite satisfactory particularly solvolysis of Ethyl Cinamate which is important for medicinal use as well as flavoring agent in cut tobacco. There for kinetic study of the solvent effect on the base catalyzed hydrolysis Ethyl Cennamate in water-methanol media of various compositions are needed to investigate which has not studies so for.…”

Thermodynamic properties study of dissolution of 2-hydroxbenzoic acid in binary solvent (ethanol+ water) at various temperatures11

“…SA is a solid weak acid the degree of dissociation is affected by the solvent. The best way to study the solvent effect on the dissociation reaction is by study the activation thermodynamic parameters (∆G, ∆H, and ∆S) for the reaction [16]. In this paper, the correlated of solubility with temperature effect of solvent on the dissociation of SA was investigated at different solvents concentrations and different temperatures.…”

Kinetic Studies of Solvent Effect of Aquo-Ehtanol Solvent System on Thermodynamic Activation Parameters of the Catalysed Solvolysis of Ethyl Nicotinate

“…Though the solvent effect on the rate and mechanism of the various type of reaction has been reported 1,2,3 , but very little attention has been paid towards the study of the solvent effect on the thermodynamic activation parameter and solventsolute interaction, particularly solvolysis of Ethyl nicotinate which is important for medicinal use. It has been proposed to make a kinetic study of the solvent effect on the base catalyzed hydrolysis Ethyl nicotinate in water-ethanol media of various compositions.…”