Solvent Effects in the Conversion of Nitriles to Perhydro-s-triazines 1

Polyacrylamide (PAAm) gels were synthesized using cross-linkers with their potential functionality (twice the number of double bonds of a cross-linker) varying from six to sixteen. Improved electrophoretic separation and highly desirable porosity and sieving properties were observed for most of the PAAm gels containing novel cross-linkers. An increase in the potential functionality of cross-linkers used in PAAm gels was an important factor, influencing the pore size and pore size distribution of the network.

Section: Synthesis Of the Novel Cross-linkersmentioning

confidence: 99%

Novel cross-linked homogeneous polyacrylamide gels with improved separation properties: Investigation of the cross-linker functionality

Patras

Qiao

2001

“…Hexahydro-1,3,5-triacryloyl-s-triazine (1a) [15] was synthesized as previously reported and was recrystallized from alcohol and employed after purification was confirmed.…”

Section: Synthesis Of the Cross-linkersmentioning

confidence: 99%

Characterization of the pore structure of aqueous three-dimensional polyacrylamide gels with a novel cross-linker

Patras¹,

Qiao²

2000

The properties of polyacrylamide hydrogels synthesized with a novel hexafunctional (three double bonds) cross-linker, hexahydro-1,3,5-triacryloyl-s-triazine (1a), was evaluated and compared to the currently used tetrafunctional (two double bonds) cross-linker N,N-methylenebisacrylamide (Bis). A variety of characterization techniques that require very little sample preparation and data handling were chosen and include polymerization temperature profiles and conversions, water swelling, differential scanning calorimetry (DSC), polyacrylamide gel electrophoresis (PAGE), Gradiflow electrophoretic separation process and scanning electron microscopy (SEM). The alternative use of 1a compared to Bis results in polyacrylamide gels with larger pore sizes and a broad pore size distribution.

“…N,N'-Bis(methacryloyl)piperazine (mPIP) (5) was prepared as described by Ferruti [9]. The symmetrical monomer triacryloylperhydro-s-triazine (TAPT) (7) and its analogue trimethacryloylperhydro-s-triazine (mTAPT) (8) were also prepared as described previously [10,11]. Solid monomers were recrystallized from ethanol unless otherwise stated.…”

Section: Chemicalsmentioning

confidence: 99%

Novel cross-linked polyacrylamide matrices: An investigation using gradient gel electrophoresis

Caulfield¹,

Purss²

2001

Gradient gel electrophoresis was used to examine the separation properties of novel cross-linking compounds for polyacrylamide (PAAm). At low %T and at the same %C protein migration difference is accentuated for bismethacrylamide cross-linked networks relative to bisacrylamide cross-linked networks. Similar properties were observed for cyclic monomers at low %T. This trend is maintained throughout the gradient. However, at higher %T migration differential relative to N,N'-methylenebisacrylamide (Bis) was less pronounced. Evidence from gradient gels suggests that reactivity and functionality of vinyl groups impose an overriding control over network formation.