Somatic and autonomic neuropathy at oncohematological diseases

Шишкина, Е. С.; Байдина, Т В; Fokina, E. S.; Minaeva, N V

doi:10.21145/2499-9954-2018-5-112-116

2018

DOI: 10.21145/2499-9954-2018-5-112-116

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Somatic and autonomic neuropathy at oncohematological diseases

Е. С. Шишкина¹,

Т В Байдина²,

E. S. Fokina³

et al.

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Polyneuropathy in POEMS Syndrome

Шишкина

Мухачева

Байдина

2020

РНЖ

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A rare version of paraproteinemic hemablastosis, with the onset characterized by Peripheral Nerve Disease, is POEMS- syndrome (Polyneuropathy, Organomegaly, Endocrinopathy, M-protein, Skin Changes). In the foreground of the clinical picture of this oncohematological disease is progressive sensorimotor polyneuropathy, which is the reason for the primary reference to a neurologist long before the provision of specialized hematological care. The article provides an overview of recent scientific publications devoted to this disease. Its pathogenetic mechanisms are discussed, as well as the basis of endothelial growth factor. The authors present their own clinical observation of a 62-year-old patient. The onset of the disease was characterized by polyneuropathy accompanied by changes in the M-protein index, organomegaly in the absence of bone-destructive changes, which made the diagnosis difficult. Additional clinical signs included fever, edema (ascites, exudative pleurisy), and hypoproteinemia, changes in peripheral blood (moderate leukocytosis with a decrease in the level of erythrocytes and platelets, which is atypical), kidney and cardiovascular damage. Despite the specific therapy, the patient’s condition was complicated by the development of infectious complications and was fatal. This clinical observation illustrates the need for a careful differential search for a possible cause of non-polyneuropathy of unknown genesis.

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Polyneuropathy in POEMS Syndrome

Шишкина

Мухачева

Байдина

2020

РНЖ

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Cardiotoxic Effects of Yew Tree and Pink Periwinkle Alkaloids

Маль

Artyushkova

Гладченко

et al. 2021

Bezopasnost' i risk farmakoterapii

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Antitumour herbal medicines based on pink periwinkle and yew tree alkaloids are included in combination therapies for many types of cancer. The use of these classes of products may entail cardiotoxic effects leading to life-threatening conditions. The aim of the study was to analyse scientific literature on cardiotoxic effects of anticancer drugs based on yew tree alkaloids (taxanes) and pink periwinkle alkaloids (vinca alkaloids). The results of the analysis demonstrated that the main manifestations of taxane-induced cardiotoxicity were bradycardia, atrioventricular block, atrial and ventricular arrhythmias. Concomitant use of taxanes and anthracycline antibiotics exacerbated cardiotoxic effects of both drug classes. The use of vinca alkaloids was associated with haematological toxicity in the form of neutropenia, while cardiotoxic effect was rarely observed during monotherapy. Raising awareness among oncologists, cardiologists, and other specialists involved in the management of cancer patients about potential cardiac complications of antitumour therapy contributes to early detection of adverse reactions and allows for individual correction of treatment regimens, especially in patients with predisposition to cardiovascular disease.

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Somatic and autonomic neuropathy at oncohematological diseases

Cited by 2 publications

References 0 publications

Polyneuropathy in POEMS Syndrome

Polyneuropathy in POEMS Syndrome

Cardiotoxic Effects of Yew Tree and Pink Periwinkle Alkaloids

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