Somatic Chromosomal Aberrations and Male Infertility

Abstract

A significant correlation was found between the frequency of chromosomally aberrant peripheral lymphocytes and a low frequency of morphologically normal spermatozoas in men. No correlation was found between increased chromosomal breakage, other sperm parameters and density, motility or agglutination of spermatozoa. Smokers had significantly more cells with aberrations than nonsmokers. The significance of induced lesions in peripheral lymphocytes and their relationship to reproduction was discussed.

Evaluation of the Genotoxicity of Spiramycine in Male Mice.

“…The results also emphasize the positive correlation between cytogenetic damage and sperm abnormalities that was reported previously in man (Nordenson et al 1984) and in mice (Devi andReddy 1985, Lavu et al 1985).…”

Somatic chromosome mutations and morphological abnormalities in sperms of boars

“…FABRICANT and PARKENING (1982) found correlation in the frequency of chromosomal aberrations and sperm abnormalities in mice of different ages. Significant correlation between the frequency of chromosomally aberrant peripheral lymphocytes and low frequency of morphologically normal sperm in humans has been shown by NORDENSON et al (1984). The authors supposed that chronic infectious agents act in a clastogenic way.…”