Some Aspects of Testing Drugs for Nephrotoxicity in Rats

Berezovskaya, I. V.; Beloshapko, A. A.; Vlasova, M. E.; Kinzyrsky, A.; Rymartsev, V. I.

doi:10.1007/978-3-642-67729-8_41

Cited by 4 publications

(1 citation statement)

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“…An analogous approach was used with the same dose of the reference agent lespenephril (a pharmaceutical sample). Experiments were performed using male rats weighing 180 -200 g. The hypoazotemic actions of PH leaf extract (preparation I) were assessed in experiments on intact animals and animals with acute renal failure (ARF) modeled by single s.c. injections of mercury (II) chloride at a dose of 4 mg/kg [9]. In both series of experiments, preparation I was given for five days (in ARF, doses started one day before injection of mercury (II) chloride).…”

Section: Notesmentioning

confidence: 99%

Chemical composition and pharmacological activity of the leaves of Pueraria hirsuta L. grown in Georgia

et al. 2008

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Phenolic compounds from Pueraria hirsuta L. grown in Georgia were studied. The leaves yielded the flavonoids robinin, nicotiphlorin, rutin, and the isoflavone glycoside daidsin; the roots yielded the isoflavones daidsin, daidsein, phormononetin, ononin, and the coumestan mirificoumestan. The dominant flavonoid in leaves was robinin, with contents of up to 1.7%. Dry extract of Pueraria hirsuta leaves containing the whole complex of biologically active compounds decreased urea, residual nitrogen, and creatinine levels in serum both in intact rats and in rats with acute renal failure induced by mercury dichloride. In terms of its hypoazotemic activity, the extract was as active as the therapeutic agent lespenephril. The functional state of the monooxygenase system of the cytoplasmic reticulum of kidney cells plays the defining role in the mechanism of the hypoazotemic action of the extract.

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Section: Notesmentioning

confidence: 99%