Some Clinical Applications of Oestrogen Assay*

Kellar, Robert J.; Matthew, G. Douglas; Mackay, Rachel B.; Brown, J. B.; Roy, Evelyn J.

doi:10.1111/j.1471-0528.1959.tb01927.x

Cited by 48 publications

(5 citation statements)

References 7 publications

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“…Furthermore, in studies on rats it has been demonstrated that oestrogen stimulates RNA and protein synthesis in the uterus in vivo (31,19). A drop in urinary oestriol excretion in the mother has been correlated to "foeto-placental insufficiency" (24,17). In our material the excretion was low in at least one case.…”

Section: -398supporting

confidence: 54%

II. After Short Gestation and Gestation Complicated by Hypertension with Special Reference to the “Small‐for‐Dates” Syndrome

Lindblad

Zetterström

1968

Acta Paediatrica

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Summary In cases of hypertensive disorder there is an increase of urea in the cord vein plasma. The increase seems to be secondary to an occasional increase in the maternal plasma. In cases of hypertensive disorder during pregnancy associated with intrauterine growth retardation of the foetus the ratio between the cord vein plasma levels and the mother's cubital vein plasma levels of essential amino acids is lower than under normal conditions. The low ratios of valine, isoleucine and leucine levels are shown to be due to higher maternal plasma levels at delivery than in normal pregnancies. It is suggested that the findings have some bearing on the growth retardation of the foetus, being the consequence of a diminished supply of essential amino acids to the foetus. The differences from what is found in normal term pregnancies are not due to a shortening of the gestational period, since there is in the foetus, in a gestational period down to 33 weeks, only still higher plasma levels of taurine and lysine. To demonstrate that the material is representative as regards hypertension and the “small‐for‐dates” syndrome a survey has been made of the weight and length at birth in cases of hypertensive disorder during pregnancy.

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Section: -398supporting

confidence: 54%

II. After Short Gestation and Gestation Complicated by Hypertension with Special Reference to the “Small‐for‐Dates” Syndrome

Lindblad

Zetterström

1968

Acta Paediatrica

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“…A preliminary communication describing the results of this application has been published (Kellar, Matthew, Mackay, Brown & Roy, 1959).…”

Section: M±0-31mentioning

confidence: 99%

A METHOD FOR THE ESTIMATION OF OESTRIOL, OESTRONE AND OESTRADIOL-17β IN THE BLOOD OF THE PREGNANT WOMAN AND OF THE FOETUS

Roy¹,

Brown²

1960

Journal of Endocrinology

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A chemical method for the estimation of oestriol, oestrone and oestradiol-17\g=b\ in the blood of the pregnant woman and of the foetus is described. It is based on a method previously developed for urine and involves acid hydrolysis of whole blood, extraction of the phenolic fraction, methylation, chromatography on alumina columns and colorimetric measurement using a micro-modification of the Kober reaction. Kober-chromogenic impurities in the final extracts are derived from the procedure, not from the blood, and are eliminated by the spectrophotometric correction of Allen. The accuracy, precision, sensitivity and specificity of the method have been determined.

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“…Ovarian endocrine activity in association with functional and non-functional secondary neoplasias has been reported by many workers who suggested that these tumours produced progesterone, oestrogens and/or androgens (Keller, Matthews, Mackay, Brown & Roy, 1959;Scully & Richardson, 1961;Van Orden, McAllister, Zerne & Morris, 1966;Scott, Lumsden & Levell, 1967). This conclusion was based on pre-and post-operative changes in the urinary excretion of metabolites of these hor¬ mones.…”

Section: Introductionmentioning

confidence: 84%

In-Vitro Steroidogenesis by an Undifferentiated Embryonal Cell Sarcoma of the Ovary

Deshpande¹,

Jensen²,

Bulbrook³

et al. 1969

Journal of Endocrinology

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Tritiated pregnenolone, 17\g=a\-hydroxypregnenolone,progesterone, 17\ g=a\ \ x=r eq-\ hydroxyprogesterone, testosterone and androstenedione were incubated separately with homogenates from an undifferentiated embryonal cell sarcoma obtained from an 11-yr.-old girl.[3H]Pregnenolone and [ 3H] 17\ g=a\ \ x=req-\ hydroxypregnenolone were converted to [3H]oestradiol-17\g=b\ in larger proportion than [3H]progesterone and [3H]17\g=a\-hydroxyprogesterone. The steroidogenesis in the sarcoma was very similar to that reported for the theca cells of the human ovarian follicle.

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Some Clinical Applications of Oestrogen Assay*

Cited by 48 publications

References 7 publications

II. After Short Gestation and Gestation Complicated by Hypertension with Special Reference to the “Small‐for‐Dates” Syndrome

II. After Short Gestation and Gestation Complicated by Hypertension with Special Reference to the “Small‐for‐Dates” Syndrome

A METHOD FOR THE ESTIMATION OF OESTRIOL, OESTRONE AND OESTRADIOL-17β IN THE BLOOD OF THE PREGNANT WOMAN AND OF THE FOETUS

In-Vitro Steroidogenesis by an Undifferentiated Embryonal Cell Sarcoma of the Ovary

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