Some clinical aspects of arylsulphatase activity

Działoszyński, L.M.; Gniot-Szulzycka, J

doi:10.1016/0009-8981(67)90001-0

Cited by 22 publications

(3 citation statements)

References 18 publications

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“…AS's have also been implicated in the pathogenesis of bladder cancer, which is the second most frequent tumor of the urogenital tract, by releasing suspected carcinogens from their detoxified sulfated conjugates [7]. Hence, high urinary AS activity has been proposed as a probable indicator of the presence of a malignant or inflammatory process [7][8][9]. In very limited studies concerning AS's, the activity of lysosomal enzyme AS-A has generally been investigated in urine due to its low concentration in serum [2].…”

Section: Introductionmentioning

confidence: 98%

Determination of diagnostic and prognostic values of urinary interleukin-8, tumor necrosis factor-α, and leukocyte arylsulfatase-A activity in patients with bladder cancer

Koçak¹,

Öner-İyidoğan²,

Koçak³

et al. 2004

Clinical Biochemistry

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Section: Introductionmentioning

confidence: 98%

Determination of diagnostic and prognostic values of urinary interleukin-8, tumor necrosis factor-α, and leukocyte arylsulfatase-A activity in patients with bladder cancer

Koçak¹,

Öner-İyidoğan²,

Koçak³

et al. 2004

Clinical Biochemistry

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“…ASB desulfates the non-reducing terminal N-acetylgalactosamine-4-sulfate residues that are present in glycosaminoglycan [ 7 ]. ASB activity is increased in different tumors tumors [ 5 , 8 - 11 ]. DM is characterized by the overproduction of ROS which affects the lysosomal membrane integrity [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

Anti-diabetic activity of different oils through their effect on arylsulfatases

Samarji

Balbaa

2014

J Diabetes Metab Disord

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BackgroundDiabetes mellitus (DM) is characterized by the overproduction of the reactive oxygen species which affects the integrity of the lysosomal membrane affecting lysosomal enzymes. The effect of these species is blocked by some natural products as antioxidants. In the current study, groups of normal and streptozotocin (STZ)-induced diabetic rats were treated by Nigella sativa (NS), olive and canola oils and subjected to the study of arylsulfatases as a model of lysosomal enzymes. The aim of the present study is to investigate the effect of STZ-induced diabetes on arylsulfatases in presence and absence of NS, olive and canola oils.MethodsDifferent groups of rats were induced by STZ, treated with different oils and compared to their corresponding control group. All groups were subjected for the assays of blood glucose, insulin, catalase and arylsulfatases. A comparative kinetic study of arylsulfatses was performed to detect the alteration of catalytic characterization.ResultsThe results demonstrated that diabetes causes a significant elevation in the level of hepatic arylsulfatase B and a significant reduction of hepatic catalase as an antioxidant enzyme. NS and olive oils returned catalase and arylsulfatase B activities back near to normal by fixing their catalytic properties. Furthermore, the maximum velocity of arylsulfatases A and B was significantly elevated in the induced diabetes, whereas their Km values were significantly changed. The treatment of diabetic rats by NS and olive oils reduced the degree of significance.ConclusionDiabetes induces significant alterations of the catalytic characters of arylsulfatases and some oils decrease this alteration through an antioxidant-mediated effect.

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“…Desde há muito sabe se que a atividade das arilsulfatases aumenta na urina e outros fluídos biológicos em diversas condições fisiológicas, como gravidez, principalmente no 3º trimestre (BAKONSKA-PACON et al, 1999)6 , e patológicas, como nos processos inflamatórios, tumores malignos (DZIALOSZYNKI & GNIOT-SZULZYCKA, 1967)42 , linfomas malignos, câncer de cólon, tumores malignos do sistema nervoso central (LAIDLER FAc-IV, de 8,0 a 18,0 kDa, ambas solúveis no citoplasma(FILBURN, 1973; ARAÚJO, MIES & MIRANDA, 1976;BAXTER & SUELTER, 1984; GRANJEIRO et al, 1997; BUZALAF et al, 1998)47,5,9,52,23 . sítio de fosforilação do receptor do fator de crescimento derivado de plaquetas (PDGF-r)127 .…”

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"Avaliação microscópica e bioquímica comparativa da membrana de osso cortical bovino desmineralizado, tratada ou não com tetraciclina, implantada em subcutâneo de ratos"

Oliveira¹,

Granjeiro²

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Agradeço primeiramente a Deus por me cercar de muitos amigos e pela melhor família que alguém poderia ter. Agradeço aos meus pais, Lourival Cardoso de Oliveira e Maria Dolores Dionízio de Oliveira, por toda sua dedicação a mim e meu irmão Rogério Cardoso de Oliveira. Por todo sofrimento que eu os fiz passar. Tenho certeza que sem eles nada do que fiz de bom ate hoje seria possível. Ao meu orientador e amigo Prof. José Mauro Granjeiro pelos seus ensinamentos e pelo seu apoio e confiança na minha pessoa. A minha eterna admiração, respeito e carinho. Ao Prof. Rumio Taga que sempre esteve auxiliando com seu imenso conhecimento. A Prof a Marília Afonso Rabelo Buzalaf pela ajuda e apoio sempre certos, sendo um dos melhores exemplos de competência e determinação para mim. Ao Prof. Eulázio Mikio Taga que para mim, como para muitos, serve de parâmetro como pesquisador pelo seu vasto conhecimento. Aos professores do Departamento de Endodontia: Clovis Bramante pela sua dedicação conosco, alunos da pós-graduação; Norberti Bernardineli pelo seu incentivo e prestação; Roberto Brandão Garcia pelo exemplo de caráter como profissional e pessoa; Ivaldo Gomes de Moraes pela atenção e pelo carinho de pai. Aos funcionários da Bioquímica Thelma, Ovídio, Pamela e Gilmar que muito fizeram para que meu trabalho desse certo e pela amizade construída nesses anos. Aos funcionários da Endodontia Edimauro, Dona Neide, Suely e Patrícia pela ajuda e apoio. Aos funcionários do Biotério Luiz, Erasmo e Richard sempre muito tolerantes com minha pesquisa. A Vera Lúcia, secretária do departamento de Ciências Biológicas pela ajuda em diversos momentos.

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Some clinical aspects of arylsulphatase activity

Cited by 22 publications

References 18 publications

Determination of diagnostic and prognostic values of urinary interleukin-8, tumor necrosis factor-α, and leukocyte arylsulfatase-A activity in patients with bladder cancer

Determination of diagnostic and prognostic values of urinary interleukin-8, tumor necrosis factor-α, and leukocyte arylsulfatase-A activity in patients with bladder cancer

Anti-diabetic activity of different oils through their effect on arylsulfatases

"Avaliação microscópica e bioquímica comparativa da membrana de osso cortical bovino desmineralizado, tratada ou não com tetraciclina, implantada em subcutâneo de ratos"

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