Some Factors in the Epidemiology of Histoplasmin Sensitivity in Williamson County, Tennessee

Zeidberg, Louis D.; Dillon, Ann; Gass, Ricardo

doi:10.2105/ajph.41.1.80

Cited by 34 publications

(3 citation statements)

References 2 publications

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“…En áreas endémicas la prevalencia puede llegar a ser hasta del 90 por ciento de -la población (27). Sin embargo, se conoce que la reacción de histoplasmina puede llegar a negativizarse con el paso del tiempo hasta en el 10 por ciento de los pacientes y volver a positivizarse en casos de reinfección (27)(28)(29).…”

Section: Resultsunclassified

Histoplasmosis. Experiencia del Hospital San Juan de Dios, Bogotá, 1954-1986

Reyes¹,

Sierra²,

Rodríguez³

et al. 1986

biomedica

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Se estudiaron 7 casos de histoplasmosis, 3 en hombres y 4 en mujeres, con edades promedio de 31,5 anos (rango entre 11 y 50 años), cuatro de los cuales provenían de áreas rurales (55,5%.En dos pacientes asintomáticos el diagnóstico se hizo casualmente por la realización de radiografías de tórax de rutina y se comprobó posteriormente con el material resecado quirúrgicamente. No requirieron tratamiento farmacológico especifico.Entre los pacientes sintomáticos las manifestaciones clínicas variaron entre cuadros leves, moderadas y severas. Un paciente presentó Úlcera en la lengua como única manifestación y el tratamiento requerido fue la extirpación total de la lesión. Dos pacientes manifestaron formas moderadas de la enfermedad por meningitis crónicas diagnosticadas por pruebas serológicas y de fijación del complemento. Sus manifestaciones fueron principalmente alteraciones de conducta, comportamiento inapropiado, deterioro intelectual, episodios psicóticos, anisocoria y alteraciones de la marcha. En una paciente se realizó tratamiento con anfotericina B sin éxito y la otra falleció después de derivación ventrículo-atrial efectuada en otra institución, la cual probablemente diseminó la enfermedad. Dos pacientes manifestaron formas severas de la enfermedad por histoplasmosis generalizada. Uno de ellos falleció y el otro presentó ascitis.Se hace revisión del tema incluyendo aspectos históricos, epidemioló-gicos, patológicos, clínicos y de diagnóstico. INTRODUCCIONActualmente se acepta que la enfermedad es de presentación universal en las áreas endémicas en las La histoplasmosis es una enfermedad micótica de que pruebas positivas de histoplasmina y la presencia origen respiratorio causada por el Histoplasma capsu-de complejos parenquimatosos y ganglionares calcifilatum, que se difunde por los vasos linfáticos pulmo-cados son considerados estigmas de la enfermedad. nares y la sangre hacia los vasos mediastinales, el (2-5) bazo, el hígado, las glándulas suprarrenales, el tubo digestivo, el riñón y otros órganos. (1-6) La histoplasmosis tiene un amplio espectro de

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Section: Resultsunclassified

Histoplasmosis. Experiencia del Hospital San Juan de Dios, Bogotá, 1954-1986

Reyes¹,

Sierra²,

Rodríguez³

et al. 1986

biomedica

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show abstract

“…Students whose drinking water came from springs showed a higher than average prevalence of positive reactions, which may reflect the same factors as those associated with old houses, for the early homes were often located near springs. Another possibility is that the soil near springs may be damp, and dampness is believed to favor the growth of H. capsulatum (6,17,(29)(30)(31).…”

Section: Prevalence Of Histoplasmin Sensttmty Among Lifetime One-housmentioning

confidence: 99%

“…Elsewhere in the nation, there were few such counties; most of them were scattered in eastern Texas and western Louisiana, along the Appalachian mountains from Bristol, Tennessee to Gettysburg, Pennsylvania, and on Maryland's Eastern Shore. But infection was not uniformly distributed within the major areas of high and low prevalence, and subsequent studies of counties and towns have shown considerable differences in the frequency of reactors to histoplasmin even within these small areas (6)(7)(8)(9)(10)(11)(12)(13)(14)(15). Indeed, variation appears to be the hallmark of the geographic distribution of histoplasmin sensitivity.…”

mentioning

confidence: 99%

Differences in the Distribution of Sensitivity to Histoplasmin and Isolations of Histoplasma Capsulatum1

Comstock¹,

Vicens

Goodman

et al. 1968

American Journal of Epidemiology

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junior and senior high school students in Washington County, Maryland were tested with histoplasmin. Among 1,450 students who were lifetime residents of a single house, there was marked geographic variation in the prevalence of histoplasmin reactors, ranging from 10 to 90% with no apparent correlation with any topographic or geographic features except for low prevalence within the city of Hagerstown. Marked variation in the frequency of histoplasmin sensitivity within short distances made it unlikely that meterologic factors were involved and suggested that infection was usually acquired close to home. No association was found with the presence of chickens or domestic birds on the premises. Students who lived on alkaline soils were more likely to have been infected than those who lived on acid soils. Positive soil cultures for Histoplasma capsvlahim did not show a similar pattern of associations, being more frequent from premises with chickens and in areas with acid soils. The discrepancies between skin sensitivity and soil isolations could result from some characteristic of the organism, such as spore size, which varied with soil conditions.

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Histoplasmosis of Lungs

Schwartz¹

1954

Arch Intern Med

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Some Factors in the Epidemiology of Histoplasmin Sensitivity in Williamson County, Tennessee

Cited by 34 publications

References 2 publications

Histoplasmosis. Experiencia del Hospital San Juan de Dios, Bogotá, 1954-1986

Histoplasmosis. Experiencia del Hospital San Juan de Dios, Bogotá, 1954-1986

Differences in the Distribution of Sensitivity to Histoplasmin and Isolations of Histoplasma Capsulatum1

Histoplasmosis of Lungs

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