2013
DOI: 10.1038/ncb2839
|View full text |Cite
|
Sign up to set email alerts
|

SON connects the splicing-regulatory network with pluripotency in human embryonic stem cells

Abstract: Human embryonic stem cells (hESCs) harbour the ability to undergo lineage-specific differentiation into clinically relevant cell types. Transcription factors and epigenetic modifiers are known to play important roles in the maintenance of pluripotency of hESCs. However, little is known about regulation of pluripotency through splicing. In this study, we identify the spliceosome-associated factor SON as a factor essential for the maintenance of hESCs. Depletion of SON in hESCs results in the loss of pluripotenc… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1
1

Citation Types

6
136
0

Year Published

2015
2015
2023
2023

Publication Types

Select...
10

Relationship

2
8

Authors

Journals

citations
Cited by 94 publications
(149 citation statements)
references
References 55 publications
6
136
0
Order By: Relevance
“…10d and Supplementary Table 6). Consistently, we noticed that SON 34 , SMARCC1 (BAF155) 35 , and TRIM28 36 were amongst the RICK-exclusive mESC RBPs. Thus, RICK can be applied to different cell types other than HeLa; further studies will be needed to ascertain the role in self-renewal/pluripotency of the newly identified candidate RBPs in mESCs.…”
Section: Resultssupporting
confidence: 75%
“…10d and Supplementary Table 6). Consistently, we noticed that SON 34 , SMARCC1 (BAF155) 35 , and TRIM28 36 were amongst the RICK-exclusive mESC RBPs. Thus, RICK can be applied to different cell types other than HeLa; further studies will be needed to ascertain the role in self-renewal/pluripotency of the newly identified candidate RBPs in mESCs.…”
Section: Resultssupporting
confidence: 75%
“…This is notable because, although multiple RNA splicing factors have been reported to control the pluripotent state of hESCs (Gabut et al, 2011;Lu et al, 2013), it has been unknown whether they also regulate its dissolution. RNA splicing has been shown in other cell types to interact with the MEK and RA pathways (Shilo et al, 2014;Wang et al, 2015).…”
Section: A High-throughput Rnai Screen Under Multiple Conditions Idenmentioning
confidence: 97%
“…Downregulation of U2AF35 and SRSF3 suppresses the efficiency of somatic cell reprogramming, suggesting that these splicing factors participate in the molecular network of pluripotency maintenance (227). Also, the splicing factor SON participates in the expression of several pluripotency factors (228). The existence of these dual splicing-transcription regulatory networks suggests that the coupling between transcription and splicing can have profound implications in the circuitry controlling complex gene expression patterns.…”
Section: Participation Of Transcriptional Coupling In Tissue-specificmentioning
confidence: 98%