Sonochemical synthesis and characterization of pure nanometer-sized Fe3O4 particles

Vijayakumar, R.; Koltypin, Yuri; Felner, I.; Gedanken, Aharon

doi:10.1016/s0921-5093(00)00647-x

Cited by 302 publications

(152 citation statements)

References 24 publications

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“…Magnetization curves (M-H loop) for the DIO-NPs measured at room temperature are presented in Figure 4. According to previous studies [44,45] the DIO-NPs, shows negligible value of coercivity which indicates the presence of superparamagnetic phase. From hysteresis measurements, the remnant magnetization (Mr) and coercivity fields (Hc) were equal to 0 Oe at 300 K. On the other hand, the calculated magnetization value of DIO-NPs was found to be 9.84 emu/g.…”

Section: Atr-ftir Spectra and Magnetic Behavior Of Dio-npsmentioning

confidence: 65%

Synthesis, Characterization, and Toxicity Evaluation of Dextran-Coated Iron Oxide Nanoparticles

Balaș

Ciobanu

Burtéa

et al. 2017

Metals

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Abstract:We report the synthesis of dextran-coated iron oxide magnetic nanoparticles (DIO-NPs) with spherical shape and uniform size distribution as well as their accumulation and toxic effects on Jurkat cells up to 72 h. The characterization of dextran-coated maghemite nanoparticles was done by X-ray diffraction and dynamic light scattering analyses, transmission electron microscopy imaging, attenuated total reflectance Fourier transform infrared (ATR-FTIR) spectroscopy, magnetic hysteresis, and relaxometry measurements. The quantification of DIO-NPs intracellular uptake showed a progressive accumulation of iron as a function of time and dose accompanied by additional lysosome formation and an increasing darkening exhibited by a magnetic resonance imaging (MRI) scanner. The cytotoxicity assays revealed a decrease of cell viability and a loss of membrane integrity in a time-and dose-dependent manner. Exposure to DIO-NPs determined an increase in reactive oxygen species level up to 72 h. In the first two days of exposure, the level of reduced glutathione decreased and the amount of malondyaldehyde increased, but at the end of the experiment, their concentrations returned to control values. These nanoparticles could be used as contrast agents for MRI but several parameters concerning their interaction with the cells should be taken into consideration for a safe utilization.

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Section: Atr-ftir Spectra and Magnetic Behavior Of Dio-npsmentioning

confidence: 65%

Synthesis, Characterization, and Toxicity Evaluation of Dextran-Coated Iron Oxide Nanoparticles

Balaș

Ciobanu

Burtéa

et al. 2017

Metals

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“…Alginate-coated superparamagnetic magnetite nanoparticles (FeONP) were synthesized by insonating ferrous and ferric salt solutions, as reported previously [8,9] ) were dissolved in 80 ml of distilled water. A black magnetic oxide precipitate was obtained by heating the solution to 80˚C in argon atmosphere, increasing the pH to 10 by adding 28% -30% ammonium hydroxide to the water, and insonating the mixed iron solution with 20-kHz ultrasound at a power output of 140 W for 1 h. Alginate was used to coat the nanoparticle surface to disperse the particles.…”

Section: Metal Nanoparticlesmentioning

confidence: 99%

Enhancement of Tumor Regression by Coulomb Nanoradiator Effect in Proton Treatment of Iron-Oxide Nanoparticle-Loaded Orthotopic Rat Glioma Model: Implication of Novel Particle Induced Radiation Therapy

Seo¹,

Jeon²,

Jeong³

et al. 2013

JCT

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Background: Proton-impact metallic nanoparticles, inducing low-energy electrons emission and characteristic X-rays termed as Coulomb nanoradiator effect (CNR), are known to produce therapeutic enhancement in proton treatment on experimental tumors. The purpose of this pilot study was to investigate the effect of CNR-based dose enhancement on tumor growth inhibition in an iron-oxide nanoparticle (FeONP)-loaded orthotopic rat glioma model. Methods: Proton-induced CNR was exploited to treat glioma-bearing SD rat loaded with FeONP by either fully-absorbed single pristine Bragg peak (APBP) or spread-out Bragg peak (SOBP) 45-MeV proton beam. A selected number of rats were examined by MRI before and after treatment to obtain the size and position information for adjusting irradiation field. Tumor regression assay was performed by histological analysis of residual tumor in the sacrificed rats 7 days after treatment. The results of CNR-treated groups were compared with the proton alone control. Results: Intravenous injection of FeONP (300 mg/kg) elevated the tumor concentration of iron up to 37 μg of Fe/g tissue, with a tumor-to-normal ratio of 5, 24 hours after injection. The group receiving FeONP and proton beam showed 65% -79% smaller tumor volume dose-dependently compared with the proton alone group. The rats receiving FeONP and controlled irradiation field by MR imaging demonstrated more than 95% -99% tumor regression compared with MRI-determined initial tumor size. Conclusions: Proton-impact FeONP produced therapeutic enhancement compared with proton alone in an orthotopic rat glioma model at a selected temporal point after treatment. Single BP proton beam could induce CNRbased dose enhancement and produce enhanced tumor regression that was comparable to SOBP treatment despite inhomogeneous tumor dose in the APBP-treated tumor. These results may suggest emergence of novel Particle Induced Radiation Therapy (PIRT) on malignant glioma.

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“…According to Cheng et al, 2005; the in vitro cytotoxicity test revealed that the magnetite particles exhibited excellent biocompatibility. Fe 3 O 4 nanoparticles are commonly produced via co-precipitation of Fe(II) and Fe(III) ions by a base, usually sodium hydroxide or aqueous ammonia (Kang et al, 1996;Hong et al, 1997;Fried et al, 2001) or they may be made by thermal decomposition of alkaline solution of Fe(III) chelate in the presence of hydrazine and by sonochemical decomposition of hydrolyzed Fe(II) salt followed by thermal treatment (Sapieszko et al, 1980;Vijayakumar et al, 2000).…”

Section: Introductionmentioning

confidence: 99%

Ca alginate as scaffold for iron oxide nanoparticles synthesis

Finotelli

Sampaio

Morales

et al. 2008

Braz. J. Chem. Eng.

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-Recently, nanotechnology has developed to a stage that makes it possible to process magnetic nanoparticles for the site-specific delivery of drugs. To this end, it has been proposed as biomaterial for drug delivery system in which the drug release rates would be activated by a magnetic external stimuli. Alginate has been used extensively in the food, pharmaceutical and biomedical industries for their gel forming properties in the presence of multivalent cations. In this study, we produced iron oxide nanoparticles by coprecipitation of Fe(III) and Fe(II). The nanoparticles were entrapped in Ca alginate beads before and after alginate gelation. XRD analysis showed that particles should be associated to magnetite or maghemite with crystal size of 9.5 and 4.3 nm, respectively. Studies using Mössbauer spectroscopy corroborate the superparamagnetic behavior. The combination of magnetic properties and the biocompatibility of alginate suggest that this biomaterial may be used as biomimetic system.

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Sonochemical synthesis and characterization of pure nanometer-sized Fe3O4 particles

Cited by 302 publications

References 24 publications

Synthesis, Characterization, and Toxicity Evaluation of Dextran-Coated Iron Oxide Nanoparticles

Synthesis, Characterization, and Toxicity Evaluation of Dextran-Coated Iron Oxide Nanoparticles

Enhancement of Tumor Regression by Coulomb Nanoradiator Effect in Proton Treatment of Iron-Oxide Nanoparticle-Loaded Orthotopic Rat Glioma Model: Implication of Novel Particle Induced Radiation Therapy

Ca alginate as scaffold for iron oxide nanoparticles synthesis

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