Sonochemically synthesized biocompatible zirconium phosphate nanoparticles for pH sensitive drug delivery application

Kalita, Himani; Kumar, Bhupender; Konar, Suraj; Tantubay, Sangeeta; Mahto, Madhusudan Kr.; Mandal, Mahitosh; Pathak, Amita

doi:10.1016/j.msec.2015.11.010

Cited by 44 publications

(39 citation statements)

References 33 publications

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“…Post 24 h drug exposure, the cells were rinsed with 1X PBS and added with MTS reagent for 2 h. The absorbance maxima were acquired at 490 nm by utilizing the microplate reader (Cytation 5 imaging reader, BioTeK, Winooski, VT, USA). The percent viable cells were calculated as previously reported method [85][86][87][88][89] .…”

Section: Determination Of Intracellular Reactive Oxygen Species (Ros)mentioning

confidence: 99%

Tannic acid inhibits lipid metabolism and induce ROS in prostate cancer cells

Nagesh

Chowdhury

Hatami

et al. 2020

Sci Rep

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Prostate cancer (PCa) cells exploit the aberrant lipid signaling and metabolism as their survival advantage. Also, intracellular storage lipids act as fuel for the PCa proliferation. However, few studies were available that addressed the topic of targeting lipid metabolism in PCa. Here, we assessed the tannic acid (TA) lipid-targeting ability and its capability to induce endoplasmic reticulum (ER) stress by reactive oxygen species (ROS) in PCa cells. TA exhibited dual effects by inhibiting lipogenic signaling and suppression of lipid metabolic pathways. The expression of proteins responsible for lipogenesis was down regulated. The membrane permeability and functionality of PCa were severely affected and caused nuclear disorganization during drug exposure. Finally, these consolidated events shifted the cell's survival balance towards apoptosis. These results suggest that TA distinctly interferes with the lipid signaling and metabolism of PCa cells.

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Section: Determination Of Intracellular Reactive Oxygen Species (Ros)mentioning

confidence: 99%

Tannic acid inhibits lipid metabolism and induce ROS in prostate cancer cells

Nagesh

Chowdhury

Hatami

et al. 2020

Sci Rep

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“…S16 of SI. We speculate that the higher release rate in the acidic buffer solution can be ascribed to the following points according to the literature 45 47 48 49 : (i) the amide and ester groups of the copolymer mPEG-PCL-mPEG become more hydrolysable under acidic conditions, thus indicating that the copolymer-based micelles are likely to be somewhat disrupted 47 ; (ii) the higher solubility of the drugs in the acidic solution 49 ; (iii) protonation of drug molecules in the acidic solution could weaken their interactions with the drug vehicle to some extent 45 . Consequently, such a release characteristic of our drug carrier, namely the increased release rate under acid conditions of tumor microenvironment, will hold great promise in the enhanced treatment of patients with malignant tumor, cancer and other diseases.…”

Section: Resultsmentioning

confidence: 75%

“…6(a–d) . To mimic the physiological pH of blood and the acidic intracellular environment in tumor cells (attributed to the metabolic end products accumulate in the tumor microenvironment 44 ), pH 7.4 and pH 5 buffer solutions were employed respectively 45 46 . Both aloin and curcumin loaded in the three hydrogel samples display typical drug release profiles, i.e.…”

Section: Resultsmentioning

confidence: 99%

Graphene oxide-enhanced sol-gel transition sensitivity and drug release performance of an amphiphilic copolymer-based nanocomposite

Wang

Lee

et al. 2016

Sci Rep

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We report the fabrication of a highly sensitive amphiphilic copolymer-based nanocomposite incorporating with graphene oxide (GO), which exhibited a low-intensity UV light-triggered sol-gel transition. Non-cytotoxicity was observed for the composite gels after the GO incorporation. Of particular interest were the microchannels that were formed spontaneously within the GO-incorporated UV-gel, which expedited sustained drug release. Therefore, the present highly UV-sensitive, non-cytotoxic amphiphilic copolymer-based composites is expected to provide enhanced photothermal therapy and chemotherapy by means of GO’s unique photothermal properties, as well as through efficient passive targeting resulting from the sol-gel transition characteristic of the copolymer-based system with improved sensitivity, which thus promises the enhanced treatment of patients with cancer and other diseases.

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“…Zirconium phosphate (ZrP) is an inorganic compound that presents interest due to its specific properties: biocompatibility [55,56], thermal stability, ion-exchange ability [57]. These characteristics make possible the utilization of ZrP in catalysis [58], drug-delivery [56], photochemistry [59], anti-corrosion protection [60]. From morphological point of view, ZrP can be found in both amorphous and crystalline form.…”

Section: Inorganic-based Flame Retardantsmentioning

confidence: 99%

Halogen-free flame retardants for application in thermoplastics based on condensation polymers

et al. 2019

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Future materials in the field of thermoplastics require a lower impact on the environment. Actual thermoplastic materials also require "greener" additives for thermal and fire resistance profile. In this work, some of the recent solutions for halogen-free flame retardants were discussed in the context of viable routes with economical and industrial relevance. The fire retardant mechanism was discussed in order to imagine new solutions for future additives. Some of the main (inorganic, organic or hybrid) flame retardants can be used as common platform for the next classes of thermoplastic composites (synthetic, natural, or bio-based). The new generation of flame retardants (based on the emerging solutions) will have to surpass two major barriers: the cost effectiveness and the need for high concentration (which usually affects other properties).

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Sonochemically synthesized biocompatible zirconium phosphate nanoparticles for pH sensitive drug delivery application

Cited by 44 publications

References 33 publications

Tannic acid inhibits lipid metabolism and induce ROS in prostate cancer cells

Tannic acid inhibits lipid metabolism and induce ROS in prostate cancer cells

Graphene oxide-enhanced sol-gel transition sensitivity and drug release performance of an amphiphilic copolymer-based nanocomposite

Halogen-free flame retardants for application in thermoplastics based on condensation polymers

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