Sonographic features of primary tumor as independent predictive factors for lymph node metastasis in papillary thyroid carcinoma

Wu, Qiong; Li, Yuehua; Wang, Y.; Hu, Baishi

doi:10.1007/s12094-015-1313-z

Cited by 21 publications

(25 citation statements)

References 23 publications

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“…The main characteristics of the 71 articles included in this meta-analysis are summarized in Table 1 [ 7 8 9 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 ]. A total of 44,034 participants with PTC were enrolled, of whom 11,132 (25.3%) had HT.…”

Section: Resultsmentioning

confidence: 99%

Associations between Hashimoto Thyroiditis and Clinical Outcomes of Papillary Thyroid Cancer: A Meta-Analysis of Observational Studies

Moon

Chung

et al. 2018

Endocrinol Metab

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BackgroundEpidemiological studies have suggested an association between Hashimoto thyroiditis (HT) and papillary thyroid cancer (PTC) development. Other studies, however, have reported a protective role of HT against PTC progression. Through this updated meta-analysis, we aimed to clarify the effects of HT on the progression of PTC.MethodsWe searched citation databases, including PubMed and Embase, for relevant studies from inception to September 2017. From these studies, we calculated the pooled odds ratios (ORs) of clinicopathologic features and the relative risk (RR) of PTC recurrence with 95% confidence intervals (CIs) using the Mantel-Haenszel method. Additionally, the Higgins I2 statistic was used to test for heterogeneity.ResultsThe meta-analysis included 71 published studies with 44,034 participants, among whom 11,132 had HT. We observed negative associations between PTC with comorbid HT and extrathyroidal extension (OR, 0.74; 95% CI, 0.68 to 0.81), lymph node metastasis (OR, 0.82; 95% CI, 0.72 to 0.94), distant metastasis (OR, 0.49; 95% CI, 0.32 to 0.76), and recurrence (RR, 0.50; 95% CI, 0.41 to 0.61).ConclusionIn this meta-analysis, PTC patients with HT appeared to exhibit more favorable clinicopathologic characteristics and a better prognosis than those without HT.

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Section: Resultsmentioning

confidence: 99%

Associations between Hashimoto Thyroiditis and Clinical Outcomes of Papillary Thyroid Cancer: A Meta-Analysis of Observational Studies

Moon

Chung

et al. 2018

Endocrinol Metab

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“…Several studies have been proposed for the LNM risk assessment of PTC patients. Some manifested that tumor size, tumor location, tumor extension, microcalcifications, and Hashimoto's disease are independent risk factor of LNM 9,[15][16][17][18] . Some combined the above risk factors with blood markers such as thyroid stimulating hormone (TSH) and antithyroglobulin antibodies (TGAb) to construct LNM prediction models for PTC patients 19,20 .…”

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confidence: 99%

Lymph node metastasis prediction of papillary thyroid carcinoma based on transfer learning radiomics

et al. 2020

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Non-invasive assessment of the risk of lymph node metastasis (LNM) in patients with papillary thyroid carcinoma (PTC) is of great value for the treatment option selection. The purpose of this paper is to develop a transfer learning radiomics (TLR) model for preoperative prediction of LNM in PTC patients in a multicenter, cross-machine, multi-operator scenario. Here we report the TLR model produces a stable LNM prediction. In the experiments of cross-validation and independent testing of the main cohort according to diagnostic time, machine, and operator, the TLR achieves an average area under the curve (AUC) of 0.90. In the other two independent cohorts, TLR also achieves 0.93 AUC, and this performance is statistically better than the other three methods according to Delong test. Decision curve analysis also proves that the TLR model brings more benefit to PTC patients than other methods.

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“…Accurate evaluation of CLNM prior to surgery is important for determining appropriate extent of lymph node dissection. A considerable body of literature shows that male gender, age of onset < 45 y, tumor size > 81.0 cm, and multifocality are associated with higher rate of CLNM in PTC [ 3 , 4 , 15 – 17 ]. Considering the impact of gender on the clinicopathological features of PTC, it is necessary to explore whether the predictive factors of CLNM differ by gender.…”

Section: Discussionmentioning

confidence: 99%

“…Preoperation risk of CLNM is important for deciding extent of surgery. Recent studies focused on the predictive risk factors for CLNM have revealed that age of onset, size of tumor, and multifocality are independently associated with CLNM in PTC [ 15 , 17 , 23 ]. It has been established that age is negatively correlated with CLNM in PTC, and the risk of CLNM increases proportionally with the number of tumor foci [ 15 , 24 ].…”

Section: Discussionmentioning

confidence: 99%

“…However, the sensitivity of US for predicting CLNM in PTC is only 23%~30.0% [ 11 , 14 ]. Studies that attempted to investigate the predictive risk factors of CLNM in PTC patients were done recently and showed that some clinical factors such as age of onset, Hashimoto's thyroiditis (HT), thyroid-stimulating hormone (TSH), size of primary tumor, multifocality, and some other US features of the primary tumor were independently correlated with CLNM in PTC patients [ 3 , 4 , 15 – 17 ].…”

Section: Introductionmentioning

confidence: 99%

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Gender-Specific Risk of Central Compartment Lymph Node Metastasis in Papillary Thyroid Carcinoma

Sun

Zhang

et al. 2018

International Journal of Endocrinology

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Our aim was to evaluate the impact of gender on the predictive factors of central compartment lymph node metastasis (CLNM) in papillary thyroid carcinoma (PTC). A retrospective study of 590 patients treated for PTC was performed. Univariate and multivariate analyses showed that gender (female; P = 0.001), age (≥45 y; P < 0.001), tumor size (>1 cm; P < 0.001), and multifocality (P = 0.004) were independent predictive factors of CLNM in PTC patients. Patients were divided into male group (n = 152) and female group (n = 438). Age (≥45 y; P = 0.001), T4 (P = 0.006) and multifocality (P = 0.024) were independent predictive risk factors of CLNM in male patients. As for female patients, age (≥45 y; P < 0.001), tumor size (>1 cm; P < 0.001), multifocality (P = 0.002), and microcalcification (P = 0.027) were independently correlated with CLNM. The sensitivity of the multivariate model for predicting CLNM in male patients was 64.9%, specificity was 82.9%, and area under the ROC curve (AUC) was 0.764. As for female patients, the sensitivity was 55.7%, specificity was 77.9%, and AUC was 0.73. This study showed that the predictive factors of CLNM indeed varied according to gender. To have a more accurate evaluation of CLNM, different predictive systems should be used for male and female patients.

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Sonographic features of primary tumor as independent predictive factors for lymph node metastasis in papillary thyroid carcinoma

Abstract: Preoperative sonographic features of primary tumor including the number, size and coexistence of HT were independent predictive factors for the state of cervical lymph node metastasis in patients with papillary thyroid carcinoma.

Cited by 21 publications

References 23 publications

Associations between Hashimoto Thyroiditis and Clinical Outcomes of Papillary Thyroid Cancer: A Meta-Analysis of Observational Studies

Associations between Hashimoto Thyroiditis and Clinical Outcomes of Papillary Thyroid Cancer: A Meta-Analysis of Observational Studies

Lymph node metastasis prediction of papillary thyroid carcinoma based on transfer learning radiomics

Gender-Specific Risk of Central Compartment Lymph Node Metastasis in Papillary Thyroid Carcinoma

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