Sonographic Incidence of Cholelithiasis in the Individual With Positive Famil History

Abstract

Background: The incidence of Cholelithiasis is definitely recognized through propelling ages, as gallbladder stones are unordinary in individuals more young then 30 years for the most part with the recurrence running from 10 to 20% of the aggregate population. It represents a major burden for healthiness global and are one of the most widely recognized issue presenting to emergency room. Ultrasound is perceived as the highest quality level for diagnosing gallstones.Objectives: The present study was aims to establish the sonographic incidence of Cholelithiasis in the individual with positive family history.Material and Method: The Cross sectional study was included 130 patients. This study was conducted at the Department of Radiology in Khyber Teaching Hospital Peshawar, Pakistan. The duration of study was from 15 July to 15 October 2019. Data was analysis by Statistical Software for Social Sciences “SPSS version 24”. Results: Overall 130 patients included in this study. Out of 130, female individuals was 85(65.4%) and male 45(34.6%). Epigastric pain was in all individuals 130(100%). Out of 130 patients, gallstones found in 76(58.4%) patients, in which males are 21(16.2%), females 55(42.3%) and the remaining 54(41.5%) patients had no stone. In 130 patients, 37(28.5%) had positive family history and 93(71.5%) negative family history.Conclusion: It is suggested that all individuals who have epigastric pain should go through process of ultrasonography. The overall prevalence of gallstone disease was 28.5%. The occurrences of gallbladder stones were revealed several folds elevated in female while contrast with male.

Ultrasonographic Evaluation of Cholelithiasis with Family History among Adults in Swabi

“…The correlation between cholelithiasis and family history observed in this cohort is particularly noteworthy, as 64% of participants diagnosed with gallstones reported a positive family history. This supports the hypothesis that familial predisposition plays a crucial role in the development of gallstone disease, resonating with findings from similar studies that highlighted genetic factors, including those affecting bile metabolism and cholesterol homeostasis, as significant contributors to the condition (15). The robust statistical analysis, employing SPSS version 25.0, enabled a detailed examination of the data, reinforcing the reliability of the findings.…”

“…Cholelithiasis is a significant global health issue due to its high prevalence and the severe complications it can cause, such as acute cholecystitis, cholangitis, and more rarely, cholangiocarcinoma (8)(9)(10)(11)(12)(13)(14). The clinical manifestations of gallstones can be quite painful, with common symptoms including severe pain at Murphy's point, dyspepsia, fever, jaundice, loss of appetite, and weight loss (15). While factors such as obesity and age are well-recognized contributors to the risk of gallstone formation, the impact of genetic predispositions, particularly family history, remains a topic of ongoing research (16).…”