Source localization of MEG sleep spindles and the relation to sources of alpha band rhythms

Manshanden, Ilonka; Munck, Jan C. de; Simon, Norman R.; Silva, Fernando H. Lopes da

doi:10.1016/s1388-2457(02)00304-8

Cited by 153 publications

(99 citation statements)

References 25 publications

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“…The present study used wholehead MEG to examine the cortical regions involved in maxima of spindle amplitude activity in healthy, normal sleeping individual subjects during a morning nap. Despite the fact that in the present study spindles were obtained from stage 2 sleep during morning nap, our results show that sleep spindles have multiple cortical sources that are seen in frontal, temporal and parietal brain regions that correspond to the previous EEG and ⁄ or MEG findings (Anderer et al, 2001;Broughton and Hasan, 1995;Gibbs and Gibbs, 1950;Ishii et al, 2003;Lu et al, 1992;Manshanden et al, 2002;Shih et al, 2000;Urakami, 2008;Zeitlhofer et al, 1997;Zygierewicz et al, 1999). In addition, a new approach for spindle localization used in this study, such as averaging spindle amplitude and localizing the source of the maximal activity, showed specific locations for the maximal spindle activity centered at precentral and postcentral gyri.…”

Section: Discussioncontrasting

confidence: 64%

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Cortical locations of maximal spindle activity: magnetoencephalography (MEG) study

Gumenyuk

Roth

Moran

et al. 2009

Journal of Sleep Research

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SUMMAR Y The aim of this study was to determine the main cortical regions related to maximal spindle activity of sleep stage 2 in healthy individual subjects during a brief morning nap using magnetoencephalography (MEG). Eight volunteers (mean age: 26.1 ± 8.7, six women) all right handed, free of any medical psychiatric or sleep disorders were studied. Whole-head 148-channel MEG and a conventional polysomnography montage (EEG; C3, C4, O1 and O2 scalp electrodes and EOG, EMG and ECG electrodes) were used for data collection. Sleep MEG ⁄ EEG spindles were visually identified during 15 min of stage 2 sleep for each participant. The distribution of brain activity corresponding to each spindle was calculated using a combination of independent component analysis and a current source density technique superimposed upon individual MRIs. The absolute maximum of spindle activation was localized to frontal, temporal and parietal lobes. However, the most common cortical regions for maximal source spindle activity were precentral and ⁄ or postcentral areas across all individuals. The present study suggests that maximal spindle activity localized to these two regions may represent a single event for two types of spindle frequency: slow (at 12 Hz) and fast (at 14 Hz) within global thalamocortical coherence.k e y w o r d s magnetoencephalography, MR-FOCUSS, sleep spindle, source localization

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Section: Discussioncontrasting

confidence: 64%

“…Thus, Manshanden et al (2002), using equivalent dipole source techniques were able to localize sleep spindles and distinct spindle activity source from alpha activity source. In that study, authors showed the common centro-parietal distribution of spindles across four individuals.…”

Section: Discussionmentioning

confidence: 98%

Cortical locations of maximal spindle activity: magnetoencephalography (MEG) study

Gumenyuk

Roth

Moran

et al. 2009

Journal of Sleep Research

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“…Interestingly, these sensorimotor areas are also prone to oscillate in the 8-20 Hz range during wakefulness (19,20). The sensorimotor ( ) rhythm is known as a conspicuous spontaneous rhythm of relaxed wakefulness, involving the sensorimotor and premotor cortices (19,21). Although they differ in several respects (1), spindles and rhythm seem functionally related.…”

Section: Difference In Cortical Activity Associated With Slow and Fasmentioning

confidence: 99%

“…On the other hand, fMRI benefits of a good spatial resolution and is sensitive to the activity in deep brain structures which can only be inferred by source reconstruction in scalp EEG or MEG data (5,21). However, assigning activation sites to microscopic neuronal ensembles or nuclei remains uncertain.…”

Section: Activity Associated With Slow and Fast Spindles In Thalami Amentioning

confidence: 99%

Hemodynamic cerebral correlates of sleep spindles during human non-rapid eye movement sleep

Schabus

Dang‐Vu

Albouy

et al. 2007

Proc. Natl. Acad. Sci. U.S.A.

446

392

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In humans, some evidence suggests that there are two different types of spindles during sleep, which differ by their scalp topography and possibly some aspects of their regulation. To test for the existence of two different spindle types, we characterized the activity associated with slow (11-13 Hz) and fast (13-15 Hz) spindles, identified as discrete events during non-rapid eye movement sleep, in non-sleepdeprived human volunteers, using simultaneous electroencephalography and functional MRI. An activation pattern common to both spindle types involved the thalami, paralimbic areas (anterior cingulate and insular cortices), and superior temporal gyri. No thalamic difference was detected in the direct comparison between slow and fast spindles although some thalamic areas were preferentially activated in relation to either spindle type. Beyond the common activation pattern, the increases in cortical activity differed significantly between the two spindle types. Slow spindles were associated with increased activity in the superior frontal gyrus. In contrast, fast spindles recruited a set of cortical regions involved in sensorimotor processing, as well as the mesial frontal cortex and hippocampus. The recruitment of partially segregated cortical networks for slow and fast spindles further supports the existence of two spindle types during human non-rapid eye movement sleep, with potentially different functional significance.H uman sleep is associated with a profound modification of consciousness and the emergence of distinct sleep oscillations. In the early stages of non-rapid eye movement (NREM) sleep, electroencephalographic recordings show characteristic spindle oscillations. In humans, spindles consist of waxing-and-waning 11-to 15-Hz oscillations, lasting 0.5-3 sec. At the cellular level, spindles are associated with substantial neuronal activity. Spindles arise from cyclic inhibition of thalamo-cortical (TC) neurons by reticular thalamic neurons. Postinihibitory rebound spike bursts in TC cells entrain cortical populations in spindle oscillations (1). These neuronal mechanisms, which involve large TC populations, are thought to shape the processing of information during light NREM sleep and participate in the alteration of consciousness that characterizes this stage of sleep.Little is known on the cerebral correlates of human spindles. Early positron emission tomography studies reported a negative relationship between thalamic cerebral blood flow and the power spectrum in the spindle frequency band (2). However, the low temporal resolution of positron emission tomography did not allow for a fine-grained characterization of the cerebral correlates of human spindles. In addition, two kinds of spindles are described in humans. Slow spindles (Ͻ13 Hz) predominate over frontal, whereas fast spindles (Ͼ13 Hz) prevail over centro-parietal areas. The difference in spindle scalp topography is also reflected by profound functional differences. These two spindling activities differ by their circadian and homeostatic regul...

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“…Recent studies using simultaneous EEG and MEG recordings have clarified multiple simultaneously activating cortical sources of two types of spindles in the centro-parietal areas [4][5][6], involving motor and sensory-motor cortex.…”

Section: Overview Of Spindles As Thalamocortical (Tc) Oscillationsmentioning

confidence: 99%

Sleep Spindles – As a Biomarker of Brain Function and Plasticity

Urakami¹,

Ioannides²,

Kostopoulos³

2012

Advances in Clinical Neurophysiology

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Source localization of MEG sleep spindles and the relation to sources of alpha band rhythms

Cited by 153 publications

References 25 publications

Cortical locations of maximal spindle activity: magnetoencephalography (MEG) study

Cortical locations of maximal spindle activity: magnetoencephalography (MEG) study

Hemodynamic cerebral correlates of sleep spindles during human non-rapid eye movement sleep

Sleep Spindles – As a Biomarker of Brain Function and Plasticity

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