The transformation of land-use and land cover in Nakhon Ratchasima province, Thailand has rapidly changed over the last few years. The major factors affecting the growth in the province arise from the huge expansion of developing areas, according to the government’s development plans that aim to promote the province as a central business-hub in the region. This development expansion has eventually intruded upon and interfered with sub-basin areas, which has led to environmental problems in the region. The scope of this study comprises three objectives, i.e., (i) to optimize the Cellular Automata (CA) model for predicting the expansion of built-up sites by 2022; (ii) to model a linear regression method for deriving the transition of the digital elevation model (DEM); and (iii) to apply Geographic Weighted Regression (GWR) for analyzing the risk of the stativity of flood areas in the province. The results of this study show that the optimized CA demonstrates accurate prediction of the expansion of built-up areas in 2022 using Land use (LU) data of 2-year intervals. In addition, the predicting model is generalized and converged at the iteration no. 4. The prediction outcomes, including spatial locations and ground-water touch points of the construction, are used to estimate and model the DEM to extract independent hydrology variables that are used in the determination of Flood Risk Susceptibility (FRS). In GWR in the research called FRS-GWR, this integration of quantitative GIS and the spatial model is anticipated to produce promising results in predicting the growth and expansion of built-up areas and land-use change that lead to an effective analysis of the impacts on spatial change in water sub-basin areas. This research may be beneficial in the process of urban planning with respect to the study of environmental impacts. In addition, it can indicate and impose important directions for development plans in cities to avoid and minimize flood area problems.