The study evaluates the characteristics of tropospheric nitrogen dioxide (NO
2
) concentrations from 2005 to 2020 in eight cities in the State of Mato Grosso do Sul (MS), Midwestern Brazil, using data available from the Ozone Monitoring Instrument (OMI). The average concentration varies from 2981 × 10
15
molecules/cm
2
in Campo Grande, where commercial, industrial and vehicular activities take place, to 2906 × 10
15
molecules/cm
2
in Corumbá and 3035 × 10
15
molecules/cm
2
in Porto Murtinho, regions of livestock and biomass burning. The results, based on the Mann–Kendall (MK) test, show a significant increase (
p
< 0.05) in the NO
2
column levels in the region. For each of the eight cities studied, a significant seasonal cycle of NO
2
columns was determined. The maximum value of NO
2
concentration was observed in the dry period, from July to September, while the minimum value was registered in the rainy period, from October to March.
Supplementary Information
The online version contains supplementary material available at 10.1007/s00703-021-00855-5.