Our aim in this research was to detect historical and future water yield coefficient evolution and attribution. Based on the calibrated and validated water yield coefficient model in the Yiluo River Basin, the coefficient for the years 2000–2020 was simulated, along with the future projection for 2030–2050 under four Shared Socioeconomic Pathways (SSP126, SSP245, SSP370, and SSP585). The spatio-temporal evolution of historical and future water yield coefficients was then analyzed. Moreover, the geographical detector model was used to detect the impacts of climate, land use, and terrain factors on the water yield coefficient. The results showed that the water yield coefficient increased by 8.53% from 2000 to 2020, with the coefficient of farmland increasing by 10.47% and that of forestland decreasing by 8.93%. The coefficient was highest under the SSP370 scenario and the lowest under the SSP585 scenario in projections for 2030–2050. Compared to 2000–2020, the coefficients of the two scenarios increased by 12.2% and 2.0%, respectively. Consequently, under the SSP370 and SSP585 scenarios, the coefficient of farmland increased by 13.2% and 2.7%, and that of the forestland decreased by 0.9% and 14.6%, respectively. Driving factors detection indicated that land use types had the strongest explanatory power affecting the water yield coefficient; the explanatory value reached 26.5% in 2000–2020 and will exceed 29.5% in 2030–2050. In addition, the interaction between any two factors was stronger than a single factor. This research provides scientific support for the precise management of watershed and water-land resources.