Special issue on “Free Radical and Redox Biochemistry of Thiols”

Radí, Rafael; Trujillo, Madia

doi:10.3109/10715762.2015.1121254

Cited by 5 publications

(13 citation statements)

References 17 publications

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“…One may run a historical review, yet many excellent and up-to-date reviews already exist in this field and we will gladly refer to them in passing [5,6,7,8]. “Special Issues” are already prevalent [9,10] and, while it is also possible to develop a new bold hypothesis [11,12,13], we have decided to take a slightly different approach. We will take this opportunity to celebrate some of the most stunning and innovative developments in RSS during the last 15 years.…”

Section: The Importance Of Being Yellowmentioning

confidence: 99%

The Reactive Sulfur Species Concept: 15 Years On

et al. 2017

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Fifteen years ago, in 2001, the concept of “Reactive Sulfur Species” or RSS was advocated as a working hypothesis. Since then various organic as well as inorganic RSS have attracted considerable interest and stimulated many new and often unexpected avenues in research and product development. During this time, it has become apparent that molecules with sulfur-containing functional groups are not just the passive “victims” of oxidative stress or simple conveyors of signals in cells, but can also be stressors in their own right, with pivotal roles in cellular function and homeostasis. Many “exotic” sulfur-based compounds, often of natural origin, have entered the fray in the context of nutrition, ageing, chemoprevention and therapy. In parallel, the field of inorganic RSS has come to the forefront of research, with short-lived yet metabolically important intermediates, such as various sulfur-nitrogen species and polysulfides (Sx2−), playing important roles. Between 2003 and 2005 several breath-taking discoveries emerged characterising unusual sulfur redox states in biology, and since then the truly unique role of sulfur-dependent redox systems has become apparent. Following these discoveries, over the last decade a “hunt” and, more recently, mining for such modifications has begun—and still continues—often in conjunction with new, innovative and complex labelling and analytical methods to capture the (entire) sulfur “redoxome”. A key distinction for RSS is that, unlike oxygen or nitrogen, sulfur not only forms a plethora of specific reactive species, but sulfur also targets itself, as sulfur containing molecules, i.e., peptides, proteins and enzymes, preferentially react with RSS. Not surprisingly, today this sulfur-centred redox signalling and control inside the living cell is a burning issue, which has moved on from the predominantly thiol/disulfide biochemistry of the past to a complex labyrinth of interacting signalling and control pathways which involve various sulfur oxidation states, sulfur species and reactions. RSS are omnipresent and, in some instances, are even considered as the true bearers of redox control, perhaps being more important than the Reactive Oxygen Species (ROS) or Reactive Nitrogen Species (RNS) which for decades have dominated the redox field. In other(s) words, in 2017, sulfur redox is “on the rise”, and the idea of RSS resonates throughout the Life Sciences. Still, the RSS story isn’t over yet. Many RSS are at the heart of “mistaken identities” which urgently require clarification and may even provide the foundations for further scientific revolutions in the years to come. In light of these developments, it is therefore the perfect time to revisit the original hypotheses, to select highlights in the field and to question and eventually update our concept of “Reactive Sulfur Species”.

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Section: The Importance Of Being Yellowmentioning

confidence: 99%

The Reactive Sulfur Species Concept: 15 Years On

et al. 2017

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“…17,19 For these reasons, it is important for the thiols to be oxidized and to form reverse disulfide bonds in order to maintain the stability of proteins. 17,26 Various studies have been conducted on oxidative stress in recent years in order to investigate the etiopathogenesis of various skin diseases. [21][22][23][24] Various hypotheses have been proposed on the cause of hyperhidrosis and these hypotheses have been researched.…”

Section: Discussionmentioning

confidence: 99%

“…The proteins that are the most susceptible and the most quickly affected are the thiols that contain a sulfhydryl group. Plasma thiols are powerful antioxidants that physiologically eliminate free radicals 17,19 . Total thiol groups are very sensitive to oxidation and, they are consumed in the first place in oxidative stress.…”

Section: Introductionmentioning

confidence: 99%

“…14,16 Oxidant substances damage macromolecules such as lipids and proteins, also micromolecules such as DNA in the cellular environment and can even lead to death. 16,17 Oxidant substances lead to the oxidative stress by decarboxylation in proteins, hydrolysis of peptide bonds, development of disulfide bonds and cross-links. 18 The proteins that are the most susceptible and the most quickly affected are the thiols that contain a sulfhydryl group.…”

mentioning

confidence: 99%

“…20 Serum values of protein thiols are an indicator of the state of antioxidants in the body. 17,20 It has been proposed that oxidative stress may play a role in the pathogenesis of numerous dermatological disorders and that thiol-disulfide homeostasis may indicate that, however, there is conflicting information in the literature about these hypotheses. 12,[21][22][23][24] Various reports have been reported in recent years claiming that oxidative stress plays a role in the etiopathogenesis of hyperhidrosis.…”

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confidence: 99%

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Can thiol‐disulfide balance be an indicator of oxidative stress for hyperhidrosis?

Akbaş

Kılınç

2021

J of Cosmetic Dermatology

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Hyperhidrosis is a skin disease characterized by excessive sweating in order to regulate the normal body temperature. [1][2][3][4][5][6] Its incidence is not fully known, however, is estimated between 1-2.8%. 3,[7][8][9][10] It is more prevalent between the ages of 20-60 (with an average age of 25). 4,10 In the literature, there are many studies that are directed to study the treatment of the disease, but there are only a few studies that are directed to investigate the causes of the disease. 7,9,11 In our country, Karaca et al. have carried out several studies in this respect. 12,13 Hyperhidrosis can be either primary or secondary depending on the presence of an underlying disease. 1,2,4,7 Primary hyperhidrosis (PHH) is the sweating in the palmoplantar, axillary, craniofacial,

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