Special Issue: “Smart and Functional Polymers”

Li, Mingqiang; Li, Yang; Ding, Jianxun

doi:10.3390/molecules24162976

Molecules

2019

DOI: 10.3390/molecules24162976

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Special Issue: “Smart and Functional Polymers”

Mingqiang Li

Yang Li

Jianxun Ding

Abstract: Polymerization provides an efficient strategy for synthesizing macromolecules with versatile functionality [...]

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2020

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Cited by 2 publications

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“…[6] In fact, the knowledge that cells and tissues feel the surrounding environment, being able to translate physical stimuli into biochemical and biological responses, has been paving the way for the development of smart materials to be applied in regenerative medicine. [7] These materials actively contribute to cell and tissue regeneration and do not just act passively for cell adhesion, growth, and proliferation. [8] They are indeed smart biomaterials that participate on the process of tissue regeneration.…”

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Physically Active Bioreactors for Tissue Engineering Applications

et al. 2020

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Tissue engineering (TE) is a dynamic and growing scientific field that merges the knowledge of different areas such as biology, physics, medicine, and engineering. [1] The TE discipline was first coined at a National Science Foundation sponsored meeting in 1987, thus originating a field that employs life sciences and engineering with the purpose of developing biologic or synthetic supports to restore, keep, or enhance tissue functions or damaged organs. [2] The classical TE approach has been mainly focusing on associating cells with a supporting matrix, also called biomaterials or scaffolds, that essentially acts as a passive template for tissue formation in vitro by allowing cells to adhere, migrate, differentiate, and produce tissue. Usually, the cells are seeded onto the scaffolds and, occasionally, growth factors are also added. The combination of cells, growth factors, and scaffold is often referred as the TE triad. [3] Nevertheless, novel approaches in TE that include the application of a biophysical stimuli to the scaffolds through the use of a bioreactor are emerging. [4] Tissue engineering (TE) is a strongly expanding research area. TE approaches require biocompatible scaffolds, cells, and different applied stimuli, which altogether mimic the natural tissue microenvironment. Also, the extracellular matrix serves as a structural base for cells and as a source of growth factors and biophysical cues. The 3D characteristics of the microenvironment is one of the most recognized key factors for obtaining specific cell responses in vivo, being the physical cues increasingly investigated. Supporting those advances is the progress of smart and multifunctional materials design, whose properties improve the cell behavior control through the possibility of providing specific chemical and physical stimuli to the cellular environment. In this sense, a varying set of bioreactors that properly stimulate those materials and cells in vitro, creating an appropriate biomimetic microenvironment, is developed to obtain active bioreactors. This review provides a comprehensive overview on the important microenvironments of different cells and tissues, the smart materials type used for providing such microenvironments and the specific bioreactor technologies that allow subjecting the cells/ tissues to the required biomimetic biochemical and biophysical cues. Further, it is shown that microfluidic bioreactors represent a growing and interesting field that hold great promise for achieving suitable TE strategies.

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Physically Active Bioreactors for Tissue Engineering Applications

et al. 2020

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Doxorubicin-loaded folate-mediated pH-responsive micelle based on Bletilla striata polysaccharide: Release mechanism, cellular uptake mechanism, distribution, pharmacokinetics, and antitumor effects

Zhang

Huang

et al. 2020

International Journal of Biological Macromolecules

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Special Issue: “Smart and Functional Polymers”

Abstract: Polymerization provides an efficient strategy for synthesizing macromolecules with versatile functionality [...]

Cited by 2 publications

References 28 publications

Physically Active Bioreactors for Tissue Engineering Applications

Physically Active Bioreactors for Tissue Engineering Applications

Doxorubicin-loaded folate-mediated pH-responsive micelle based on Bletilla striata polysaccharide: Release mechanism, cellular uptake mechanism, distribution, pharmacokinetics, and antitumor effects

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