Specific bio-recognition reactions observed with an integrated Mach–Zehnder interferometer

Weisser, Michael; Tovar, Günter E. M.; Mittler‐Neher, Silvia; Knoll, Wolfgang; Brosinger, Franz; Freimuth, H.; Lacher, M.; Ehrfeld, W.

doi:10.1016/s0956-5663(98)00124-9

Cited by 92 publications

(36 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A Mach-Zehnder interferometer has been applied in biosensing on planar waveguides [95,96] or optical fibers [97]. A Fabry-Perot interferometric approach was utilized on a porous silicon substrate [98].…”

Section: Sensing Schemesmentioning

confidence: 99%

Miniature fiber-optic multicavity Fabry–Perot interferometric biosensor

et al. 2005

View full text Add to dashboard Cite

(ABSTRACT)Fiber-optic Fabry-Perot interferometric (FFPI) sensors have been widely used due to their high sensitivity, ease of fabrication, miniature size, and capability for multiplexing. However, direct measurement of self-assembled thin films, receptor immobilization process or biological reaction is limited in the FFPI technique due to the difficulty of forming Fabry-Perot cavities by the thin film itself. Novel methods are needed to provide an accurate and reliable measurement for monitoring the thin-film growth in the nanometer range and under various conditions. In this work, two types of fiber-optic multicavity Fabry-Perot interferometric (MFPI) sensors with built-in temperature compensation were designed and fabricated for thin-film measurement, with applications in chemical and biological sensing. Both the tubing-based MFPI sensor and microgap MFPI sensor provide simple, yet high performance solutions for thin-film sensing. The temperature dependence of the sensing cavity is compensated by extracting the temperature information from a second multiplexed cavity. This provides the opportunity to examine the thin-film characteristics under different environment temperatures.To demonstrate the potential of this structure for practical applications, immunosensors were fabricated and tested using these structures. Self-assembled polyelectrolytes served as a precursor film for immobilization of antibodies to ensure they retain their biological activity. This not only provides a convenient method for protein immobilization but also presents the possibility of increasing the binding capacity

show abstract

Section: Sensing Schemesmentioning

confidence: 99%

Miniature fiber-optic multicavity Fabry–Perot interferometric biosensor

et al. 2005

View full text Add to dashboard Cite

show abstract

“…Having in mind LoC applications, micro-optics devices such as interferometers have already been reported [14]. Nevertheless, the presented device is an step forward due to its high integration degree, with self-alignment structures, collimation lenses, air mirrors and beam splitters.…”

Section: Designmentioning

confidence: 99%

Poly(dimethyl-siloxane) (PDMS) based micro-optical beam splitters

Vila-Planas¹

2012

Opt. Pura Apl.

View full text Add to dashboard Cite

ABSTRACT:A micro-optical beam splitter for integrated optical devices has been designed, fabricated and characterized. Two main configurations of the beam splitters are defined: 1×2 and 1×4. The fabrication is based on soft-lithography and requires a single photolithographic step for master definition. The device is replicated in poly(dimethyl-siloxane) (PDMS). Its working principle is based on total internal reflection. Optical elements e.g., lenses, mirrors and beam splitters, based on PDMS and air as constituent materials are defined. A self alignment system for optical fibers has been also fabricated. Losses of 7.8 ± 1.2 dB for a single beam division are obtained.

show abstract

“…We have taken refractive index for biomolecules equal to 1.46 [38,39]. Refractive index for water was estimated by the equation adopted from [40] …”

Section: Theorymentioning

confidence: 99%

Comparative analysis of response modes for gold nanoparticle biosensor based on localized surface plasmon resonance

Lopatynskyi¹,

Lopatynska²,

Chegel³

et al. 2011

Semicond. Phys. Quantum Electron. Optoelectron.

View full text Add to dashboard Cite

Abstract. The theoretical comparison of possible response measurement techniques for a biosensor based on localized surface plasmon resonance (LSPR) in spherical Au nanoparticle was made. The methods for measuring LSPR response considered differed in the treatment of the change of light extinction spectrum along the wavelength and extinction coordinate axes upon the formation of dense biomolecular monolayer on the surface of the sensitive element. In addition, the transformation of the extinction LSPR band with increase of the nanoparticle radius from 5 to 125 nm was investigated towards the optimization of LSPR response for dipolar and quadrupolar LSPR extinction peaks.A novel method for the measurement of wavelength shift was introduced and demonstrated to be more effective for estimation of the LSPR biosensor response as compared to commonly measured extinction peak shift. These techniques were proved to produce maximal LSPR response when large-size Au nanoparticle (with a radius of 125 nm) was used as a sensitive element of biosensor. The preferable mode of extinction difference measurement turned out to be , which is carried out at a wavelength of the extreme extinction spectrum derivative on a right slope of the LSPR peak. For this method, optimal nanoparticle radii were found to be about 40 nm for the dipolar LSPR peak and near 100-105 nm for the quadrupolar one.right V

show abstract

Specific bio-recognition reactions observed with an integrated Mach–Zehnder interferometer

Cited by 92 publications

References 17 publications

Miniature fiber-optic multicavity Fabry–Perot interferometric biosensor

Miniature fiber-optic multicavity Fabry–Perot interferometric biosensor

Poly(dimethyl-siloxane) (PDMS) based micro-optical beam splitters

Comparative analysis of response modes for gold nanoparticle biosensor based on localized surface plasmon resonance

Contact Info

Product

Resources

About