Specific Protein Detection Using Thermally Reduced Graphene Oxide Sheet Decorated with Gold Nanoparticle‐Antibody Conjugates

Mao, Shun; Lu, Ganhua; Yu, Kehan; Bo, Zheng; Chen, Junhong

doi:10.1002/adma.201000520

Cited by 462 publications

(323 citation statements)

References 46 publications

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“…Recently, graphene based materials have been widely studied for sensing applications, e.g., in strain sensors,52, 141, 142, 143 temperature sensors,144 biosensors,145, 146, 147, 148 and gas sensors,72, 81, 149 as shown in Figure 19 . Nanographene films grown by PECVD have been transferred onto polydimethylsilxane (PDMS) with prestrain 51.…”

Section: Applications Of Graphene Grown By Pecvdmentioning

confidence: 99%

Controllable Synthesis of Graphene by Plasma‐Enhanced Chemical Vapor Deposition and Its Related Applications

et al. 2016

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Graphene and its derivatives hold a great promise for widespread applications such as field‐effect transistors, photovoltaic devices, supercapacitors, and sensors due to excellent properties as well as its atomically thin, transparent, and flexible structure. In order to realize the practical applications, graphene needs to be synthesized in a low‐cost, scalable, and controllable manner. Plasma‐enhanced chemical vapor deposition (PECVD) is a low‐temperature, controllable, and catalyst‐free synthesis method suitable for graphene growth and has recently received more attentions. This review summarizes recent advances in the PECVD growth of graphene on different substrates, discusses the growth mechanism and its related applications. Furthermore, the challenges and future development in this field are also discussed.

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Section: Applications Of Graphene Grown By Pecvdmentioning

confidence: 99%

Controllable Synthesis of Graphene by Plasma‐Enhanced Chemical Vapor Deposition and Its Related Applications

et al. 2016

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“…Mao et al 74 demonstrated a specific protein detection biosensor using reduced GO sheets decorated with Au nanoparticle-antibody conjugates (Figure 6a). The response of the sensor increases with the increase of protein concentrations and saturates at 0.02 mg ml À1 .…”

Section: Grapheneàstrategies To Increase Sensitivitymentioning

confidence: 99%

Carbon nanomaterials field-effect-transistor-based biosensors

2012

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Carbon nanomaterials field-effect transistor (FET)-based electrical biosensors provide significant advantages over the current gold standards, holding great potential for realizing direct, label-free, real-time electrical detection of biomolecules in a multiplexed manner with ultrahigh sensitivity and excellent selectivity. The feasibility of integrating them with current complementary metal oxide semiconductor platform and a fluid handling module using standard microfabrication technology opens up new opportunities for the development of low-cost, low-noise, portable electrical biosensors for use in practical future devices. In this article, we review recent progress in the rapidly developing area of biomolecular interaction detection using FET-based biosensors based on the carbon nanomaterials single-walled carbon nanotubes (SWNTs) and graphene. Detection scenarios include DNA-DNA hybridization, DNA-protein interaction, protein function and cellular activity. In particular, we will highlight an amazing property of SWNT-or graphene-FETs in biosensing: their ability to detect biomolecules at the single-molecule level or at the single-cell level. This is due to the size comparability and the surface compatibility of the carbon nanomaterials with biological molecules. We also summarize some current challenges the scientific community is facing, including device-to-device heterogeneity and the lack of system integration for uniform device array mass production. Keywords: biosensor; carbon nanotube; field-effect transistor; graphene A biosensor is an analytical device that incorporates a biological recognition element in direct spatial contact with a transduction element. This integration ensures the rapid and convenient conversion of the biological events to detectable signals. 1 With the discovery of rich nanomaterials and the development of exquisite nanofabrication tools, such as electron beam lithography, focused ion beam and nanoimprint lithography, new avenues have been opened up in the field of biosensors in the last two decades. 2,3 In particular, researchers around the world have been tailor-making a multitude of nanomaterials-based electrical biosensors and developing new strategies to apply them in ultrasensitive biosensing. Examples of such nanomaterials include carbon nanotubes, 4-13 nanowires, 11,14-21 nanoparticles, 6,22-25 nanopores, 26,27 nanoclusters 28 and graphene. 5,[29][30][31][32] Compared with conventional optical, biochemical and biophysical methods, nanomaterial-based electronic biosensing offers significant advantages, such as high sensitivity and new sensing mechanisms, high spatial resolution for localized detection, facile integration with standard wafer-scale semiconductor processing and label-free, real-time detection in a nondestructive manner.Among diverse electrical biosensing architectures, devices based on field-effect transistors (FETs) have attracted great attention because they are an ideal biosensor that can directly translate the interactions between target biological mole...

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“…Furthermore, the HRG/Au based nanocomposites have been applied as FET (field effect transistor) biosensors for the detection of proteins. 533,534 The FET biosensor was fabricated by suspending thermally reduced graphene oxide (TRG) sheets above the substrates across the gold electrode. When the protein was introduced, it induced changes in the electrical characteristics of the device, which were investigated by FET and direct current measurements.…”

Section: Biosensorsmentioning

confidence: 99%

Graphene based metal and metal oxide nanocomposites: synthesis, properties and their applications

et al. 2015

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Specific Protein Detection Using Thermally Reduced Graphene Oxide Sheet Decorated with Gold Nanoparticle‐Antibody Conjugates

Cited by 462 publications

References 46 publications

Controllable Synthesis of Graphene by Plasma‐Enhanced Chemical Vapor Deposition and Its Related Applications

Controllable Synthesis of Graphene by Plasma‐Enhanced Chemical Vapor Deposition and Its Related Applications

Carbon nanomaterials field-effect-transistor-based biosensors

Graphene based metal and metal oxide nanocomposites: synthesis, properties and their applications

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