Specific Proteins in Relation with Iron Overload in Experimental Study

Ahmadi, Mirela; Nicula, Mărioara; Dumitrescu, Gabi; Ştef, Lavinia; Peţ, Ioan; Ciochină, Liliana Petculescu; Dronca, Dorel

doi:10.37358/rc.18.10.6613

Cited by 5 publications

(5 citation statements)

References 12 publications

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“…The concentration of total serum proteins achieve the constant called proteinemia, which depends on hormonal and hydric balance of body, on state of nutrition and on numerous factors that influence the health of body [11,23].…”

Section: Resultsmentioning

confidence: 99%

Researches on Blood Biochemical Variations During Pregnancy in Rabbits

Lazăr¹,

Vintu²,

P³

et al. 2019

Rev. Chim.

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The organism as a biological system, for the normal performance of its functions, needs a wide variety of substances that it needs to obtain from the environment. Their assurance must be rhythmic and balanced in qualitative and quantitative terms. By its chemical composition, the blood plasma transports the energetic and plastic substances from the forming organs to the cells and tissues, but also the products resulting from the cellular and tissue catabolism of the excretory organs. The research was carried out on the Meuse Rabbit by the Belgian Giant, divided into three experimental NP groups (adult, non-pregnant females), P1 (females at 15 days of gestation) and P2 (females at the end of gestation, 30 days). The collection of blood samples was performed with the vacuum system before meals. Subsequently, they were centrifuged at 3000 rpm for 5 minutes to obtain the plasma required for the biochemical examination. Biochemical parameters were determined by spectophotometry using the ACCENT 200. As a result, we observed that gestation is a diabetogenic stress, the fetus uses glucose almost exclusively as an energy source and increases protein needs due to the permanent transfer of amino acids to the fetus. Lipid metabolism is diverted with priority to lipid consumption, about 20% of free circulating fatty acids are transferred to the fetus.

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Section: Resultsmentioning

confidence: 99%

Researches on Blood Biochemical Variations During Pregnancy in Rabbits

Lazăr¹,

Vintu²,

P³

et al. 2019

Rev. Chim.

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“…From dietary intake only about 10% from ingested iron is absorbed (about 10-20mg) every day and the iron in excess is excreted via renal function. If the kidney function is altered the homeostasis of iron could be disturb, and the iron concentration will increase and could lead to toxicity effects [4].…”

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confidence: 99%

Influence of Iron Administration on Kidney Serum Parameters

Dronca¹,

Peţ²,

Ştef³

et al. 2020

Rev.Chim.

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Some minerals are essential nutrients for organisms being necessary in different quantities, but any homeostasis disturbance (deficiency or excess) can lead to various diseases. Iron in the body plays a critical role being directly involved in the respiration process - more precisely O2 and CO2 transportation, and also in beneficial oxidation-reduction processes. But sometimes the iron can also lead to the formation of substances with toxicogenic potential, more precisely to free radicals formed as a result of oxidative stress. In the liver, there is a specialized protein - hepcidin - which is the key regulator of circulating iron in the organism. In several cases of overdose, this protein blocks the iron transportation, binds it to the export channels of ferroportin and finally sends the excess iron to the kidney for urinal excretion. Our experiment tried to evaluate if in case of iron intraperitoneal administration in excess to rabbits, for a short period of time, it influences the serum creatinine, uric acid, and blood urea nitrogen if the rabbits were fed with a special organic diet. The results of the experiment presented a lower concentration of creatinine (with 24.46%), uric acid (with more than 41.48%), and blood urea nitrogen - BUN (6.45%) for experimental rabbits compared to the control group, proving that a well-documented diet influences the accumulation and excretion of excess iron. Keywords: iron, creatinine, uric acid, blood urea nitrogen

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“…Zinc, copper, manganese, iron, chromium, and lead can interfere with the normal function of hundreds of vital metallo-enzymes [27]. Other experimental studies presented synergic and antagonistic effects between minerals after intoxication of rabbits of rats with zinc, manganese, or lead with, or without natural products as toxicological protectors [28][29][30][31][32][33].…”

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confidence: 99%

Synergic and Antagonistic Action of Active Principles on Chromium-Lead Antagonism - in vivo Experiments

Nicula¹,

Păcală²,

Ştef³

et al. 2019

Rev. Chim.

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Heavy metal pollution of the aquatic environment has become a major concern for the world. As natural water pollutants, heavy metals are among the most toxic due to their cumulative effect and the difficulty of being converted into insoluble compounds in the surface waters. Lead and its compounds are toxic to aquatic organisms, especially fish, even at low concentrations, being able to replace essential elements from the organism. Thus, we tested the concentration of chromium in tissues of Prussian carp�s fingerlings, exposed to chronic lead intoxication, following the synergic and antagonistic effects of some active principles from garlic and chlorella in various tissues. Our experiment was performed on 120 Prussian carps for 21-days as following: C group (without treatment), E1 group (75 ppm Pb into water as Pb(NO3)2 x �H2O), E2 group (75 ppm Pb into water+2% freeze dried garlic in feed), E3 group (75 ppm Pb into water + 2% freeze-dried chlorella in feed). At the end of the experimental period, tissue samples (gills, muscle, heart, skin and scales, intestine, liver, brain, gonads, and kidney) were sampled after anaesthesia. Atomic Absorption Spectrometry was used to determination of chromium concentrations in tissues. Our results revealed that freeze-dried garlic presented antagonistic effect between administrated lead and tested chromium concentration, while the chlorella showed antagonistic and synergic action, depending on the organ tissue that we had analysed.

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Specific Proteins in Relation with Iron Overload in Experimental Study

Cited by 5 publications

References 12 publications

Researches on Blood Biochemical Variations During Pregnancy in Rabbits

Researches on Blood Biochemical Variations During Pregnancy in Rabbits

Influence of Iron Administration on Kidney Serum Parameters

Synergic and Antagonistic Action of Active Principles on Chromium-Lead Antagonism - in vivo Experiments

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