Specificity and sensitivity of preoperative total serum prostate specific antigen in diagnosis most common histopathological change of prostate

Mijović, Milica; Vukićević, Danica; Djerkovic, Branislav; Savic, Sladjana; Vitković, Leonida; Nedeljković, V.

doi:10.5937/pramed1702007m

Praxis Med

2017

DOI: 10.5937/pramed1702007m

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Specificity and sensitivity of preoperative total serum prostate specific antigen in diagnosis most common histopathological change of prostate

Milica Mijović¹,

Danica Vukićević²,

Branislav Djerkovic³

et al.

Abstract: Odre ivanje preoperativnih vrednosti serumskog prostata specifi nog antigena (PSA) predstavlja primarnu proceduru u dijagnozi razli itih patoloških promena u prostati (karcinoma prostate-KP, prostati ne intraepitelne neoplazije-PIN i benigne hiperplazije prostate-BHP), nakon ega sledi digitorektalni pregled i biopsija prostate kao zlatni standard. Me utim, visoka senzitivnost i niska specifi nost PSA testa u dijagnozi karcinoma prostate (KP) predstavlja problem u klini koj praksi. Cilj rada je utvrditi dijagno… Show more

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Cited by 2 publications

References 47 publications

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Clinical-morphological characteristics of pathological changes in the prostate

Ilić¹,

Denović²

2018

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The most significant prostate diseases (PD) are benign prostatic hyperplasia (BPH), prostatic intraepithelial neoplasia (PIN) and prostate cancer (PC). Generally, all PD are rare before the age of 50 with growing number of patients, primarily with BHP, with each next decade, but about decade later the highest number of PIN and PC began to report. The aim of this paper is to examine some of clinical, biochemical and histopathological characteristics of BPH, PIN and PC. Our sample consisted of 169 men. Statisticaly the most common PD was BPH-77.5%, and the rarest PIN-8.3% (p<0.001). The average age of patients was 70.6±7.5 years (51-89) with no significant differences between diagnosis (p=0.415). PIN and PC are more often found in people from urban areas (p=0.004). In the central prostate area BPH is significantly higher in 88.5% (p<0.001). Peripheral parts are significantly more common places of PIN and PC (p<0.001). Median serum PSA values is statistically highest in PC-87.2 ng/ml (12.7-372.5), (p<0,001), especially those with predominantly peripheral parts localization. Gleason score is an important prognostic factor, with average value at PC is 7.32±1.4 (5-10), with a significantly higher values for diffuse PC. BPH is the most common, and PIN rarest PD. All diseases have occurred in people older than 50 years. Usually, BPH is in central and PIN and PC in peripheral prostate parts. PSA values were highest at PC, which is a prove of its importance in malignancy early detection.

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Clinical-morphological characteristics of pathological changes in the prostate

Ilić¹,

Denović²

2018

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Diagnostic, prognostic and predictive parameters in prostate cancer

Mijović¹,

Nedeljković²,

Vukićević³

et al. 2019

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Prostate cancer (CP) is the most common malignancy in men in America, while it is the second most common in Europe. It is responsible for about 10% of cancer deaths in the same population. It is clinically manifested in various forms, from slow-growing to aggressive forms with pronounced metastatic potential. Diagnosis is made by a well-defined algorithm, which begins with the determination of serum prostate specific antigen values and ends with prostate biopsy as the "gold standard". Pathohistological diagnostic criterias are based on architectural, cytoplasmic, nuclear and characteristics of intraluminal structures, as well as periacinar cleftings, which are deffined as helpfull diagnostic criteria of undoubted importance. Prognostic and predictive parameters are classified into three categories. Some of them are an integral part of routine pathohistologicat report, while others are considered as the diagnostic process progresses. Modern knowledge introduces biomarkers into the everyday practice of personalized medicine, especially when is necessary to treat prostate cancer patients.

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Specificity and sensitivity of preoperative total serum prostate specific antigen in diagnosis most common histopathological change of prostate

Cited by 2 publications

References 47 publications

Clinical-morphological characteristics of pathological changes in the prostate

Clinical-morphological characteristics of pathological changes in the prostate

Diagnostic, prognostic and predictive parameters in prostate cancer

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