Spectrophotometric determination of aspirin by trans acetylation of 4-aminophenol

Verma, Krishna K.; Jain, Archana

doi:10.1021/ac00295a037

Cited by 28 publications

(6 citation statements)

References 28 publications

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“…In the drug absorption experiments, ASA was dissolved in 20 mM phosphate-buffered saline (PBS) solution (7 mL; pH 7.4), followed by the addition of CD-g-CMC hydrogel (30 mg) to the ASA-containing buffer. Absorption experiments were then conducted in a thermostatcontaining reciprocal shaker (120 rpm) at 25 °C for 24 h. At different time intervals, the mixture was filtered through a membrane filter (pore size: 0.45 μm); ASA concentration in the filtrate was determined at a wavelength of 234 nm [48] using an Epoch 96 well micro-volume spectrophotometer (BioTek Instruments, Inc., US). The amount of ASA absorbed in the hydrogels (q) was determined using Eq.…”

Section: Drug Absorption and Release Studiesmentioning

confidence: 99%

Cyclodextrin-grafted chitosan hydrogels for controlled drug delivery

Kono

Teshirogi

2015

International Journal of Biological Macromolecules

102

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A series of β-cyclodextrin-grafted carboxymethyl chitosan hydrogels (CD-g-CMCs) were prepared from carboxymethyl chitosan (CMC) and carboxymethyl β-chitosan (CMCD) using a water-soluble carbodiimide as a crosslinker in the presence of N-hydroxysuccinimide. Details of the hydrogel structures were determined via FTIR and solid-state NMR spectroscopic analyses. Increasing the feed ratio of CMCD to CMC in the reaction mixture led to an increase in CD grafting within the gel networks comprising CMC; this was confirmed by SEM observations and rheological analysis of the swollen hydrogels. The prepared CD-g-CMC hydrogels exhibited absorption properties toward acetylsalicylic acid (ASA, or Aspirin) due to the presence of CD in the structure; the amount of ASA absorbed into the hydrogels was enhanced with an increase in the amount of CD incorporated within the hydrogels. In addition, CD-g-CMC hydrogels provided a slower release of the entrapped ASA in comparison to the ASA release profile of a solely CMC-containing hydrogel. From these results, CD-g-CMC hydrogels have the potential to function as a biodegradable active material with controlled drug release ability.

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Section: Drug Absorption and Release Studiesmentioning

confidence: 99%

Cyclodextrin-grafted chitosan hydrogels for controlled drug delivery

Kono

Teshirogi

2015

International Journal of Biological Macromolecules

102

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“…A great deal numbers of analytical methods for the determination of ASA have been developed. The techniques used include spectrophotometry [6,7], spectrofluorimetry [8], high-performance liquid chromatography (HPLC) [9,10], Raman spectroscopy [11,12], and gas chromatography [13,14]. Recently, the determination of ASA with electrochemical methods has caught much attention because of its sensitivity and simplicity.…”

Section: Introductionmentioning

confidence: 99%

Electrocatalytic oxidation of acetylsalicylic acid at multiwalled carbon nanotube-alumina-coated silica nanocomposite modified glassy carbon electrodes

Tsai

2010

Sensors and Actuators B: Chemical

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“…Several other methods for ASA determination in pharmaceuticals formulations, some of them combined with a flow-injection system, were also proposed; for example, the quantitative reflectance spot test, 8 spectrophotometric, [9][10][11] fluorimetric, 12 and chromatographic 13,14 methods. The use of HPLC is preferred over other methods because of the possibility of simultaneous determination of ASA and SA.…”

Section: Introductionmentioning

confidence: 99%

Square-wave voltammetric determination of acetylsalicylic acid in pharmaceutical formulations using a boron-doped diamond electrode without the need of previous alkaline hydrolysis step

Sartori¹,

Medeiros²,

Rocha‐Filho³

et al. 2009

J. Braz. Chem. Soc.

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Neste trabalho descreve-se a determinação do ácido acetilsalicílico (ASA) em formulações farmacêuticas empregando voltametria de onda quadrada (SWV) e um eletrodo de diamante dopado com boro (BDD). Neste método, ASA é determinado diretamente em solução de H 2 SO 4 0,01 mol L -1 , sem a necessidade da hidrólise alcalina. Foi obtido um único pico de oxidação no potencial de 1,97 V vs. Ag/AgCl (KCl 3,0 mol L -1 ) com características de uma reação irreversível. A curva analítica obtida é linear na faixa de concentração ASA de 2,50 × 10 -6 -1,05 × 10 -4 mol L -1 , com um limite de detecção de 2,0 µmol L -1 . O desvio padrão relativo foi menor que 1,4% para uma solução de ASA 45 µmol L -1 (n = 10). O método proposto foi aplicado com sucesso para a determinação de ASA em várias formulações farmacêuticas e os resultados obtidos foram concordantes com um método oficial da Farmacopéia Britânica, a um nível de confiança de 95%.In this paper the determination of acetylsalicylic acid (ASA) in pharmaceutical formulations using square-wave voltammetry (SWV) and a boron-doped diamond electrode (BDD) is described. By this proposed method, ASA is directly determined in a 0.01 mol L -1 H 2 SO 4 solution without the need of a previous time-consuming alkaline hydrolysis step. A single oxidation peak at a potential of 1.97 V vs. Ag/AgCl (3.0 mol L -1 KCl) with the characteristics of an irreversible reaction was obtained. The obtained analytical curve is linear in the ASA concentration range 2.50 × 10 -6 -1.05 × 10 -4 mol L -1 , with a detection limit of 2.0 µmol L -1 . The obtained relative standard deviation was smaller than 1.4% for a 45 µmol L -1 ASA solution (n = 10). The proposed method was applied with success in the determination of ASA in several pharmaceutical formulations; the obtained results were in close agreement, at a 95% confidence level, with those obtained using an official method of the British Pharmacopoeia.Keywords: acetylsalicylic acid determination, boron-doped diamond electrode, square-wave voltammetry, pharmaceutical formulations IntroductionAcetylsalicylic acid (ASA), shown in Figure 1, more popularly known as aspirin, is one of the oldest medicines that still plays an important role in modern therapeutics. It is widely employed in pharmaceutical formulations for the relief of headaches, fever, muscular pain, and inflammation due to arthritis or injury. It was first synthesized in 1897, by Felix Hoffmann, in the Farbenfabrik Freidrich Bayer laboratories, in Elberfeld, Germany. 1,2 The high consumption of this substance all over the world 3,4 indicates the importance of the development of new analytical methods to assess not only the quality but also the authenticity of the product.The rate of decomposition of ASA to salicylic acid (SA) and acetic acid (AA) is dependent on solution pH and temperature. In the pH range 11-12 ASA is quickly hydrolyzed, in the pH range 4-8 its hydrolysis rate is slow, and maximum stability is attained at pH 2-3. 5 Commonly, ASA is indirectly determined after its conversion to SA ...

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Spectrophotometric determination of aspirin by trans acetylation of 4-aminophenol

Cited by 28 publications

References 28 publications

Cyclodextrin-grafted chitosan hydrogels for controlled drug delivery

Cyclodextrin-grafted chitosan hydrogels for controlled drug delivery

Electrocatalytic oxidation of acetylsalicylic acid at multiwalled carbon nanotube-alumina-coated silica nanocomposite modified glassy carbon electrodes

Square-wave voltammetric determination of acetylsalicylic acid in pharmaceutical formulations using a boron-doped diamond electrode without the need of previous alkaline hydrolysis step

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