Spectrophotometric Determination of Phenylephrine Hydrochloride in Pharmaceutical Preparations by Oxidative Coupling Reaction

Abstract

Phenylephrine is a medication mainly applied as a decongestant to relieve hemorrhoids, increase blood pressure, and dilate the pupil. It is the first-line choice for prevention and treatment of hypotension during spinal anesthesia for cesarean section. However, many methods were used for the determination of this drug and its properties. This paper proposes a method that uses N, N dimethyl-p-phenylenediamine dihydrochloride as a new chromogenic reagent (NNDPH). This method is based on the oxidative coupling reaction of phenylephrine with N, N dimethyl-p-phenylenediamine dihydrochloride with ferric chloride in basic media to form green-blue soluble dye product. The outcomes demonstrate that the maximum absorption is at 680 nm, molar absorptivity of 5.54 × 103 mol-1.cm-1, and Sandell’s sensitivity of 0.038 μg.cm-2. The concentration range of 4 to 22 μg.mL-1 of the product is conformable to Beer’s law. Furthermore, it is applied successfully for estimating the drug properties on a simple condition or pharmaceutical preparations.

Development of a new indirect method for the determination of Trifluuperazine HCl in pharmaceutical formulations.

“…Different quantities of trifluoperazine hydrochloride were taken from the samples of pharmaceutical and the proposed method was applied, and the results are shown in the table)9(. It can be inferred from the result in Table (9) that the recovery rate is very good, which indicates that the method has good accuracy and efficiency in estimation. The value of t that was calculated for concentrations 10 and 30 for the drug 1mg and for concentrations 10 and 50 for the drug 5mg for Samarra Pharmaceutical Company available in the local market is less than the tabular value and with degrees of freedom 4 and at a confidence level of 95%, which indicates the success of the proposed method under study.…”

“…Various spectrophotometric methods used these methods included oxidative coupling reaction. [5][6][7][8][9][10] Ultraviolet spectrophotometric 11 . Also, other types of techniques have been used: indirect atomic absorption method 12 .…”

New Ion Selective Electrodes for Analysis of Metformin Based on Molecularly Imprinted Polymers

“…The functional monomer model can be accommodated by the cross-linkers and the monomer's chemical connections. After polymerization, the template can be removed, revealing binding sites with new forms, sizes, and chemical characteristics [8][9][10][11]. A biguanide antihyperglycemic drug is metformin.…”

Validated First-Order Derivative Ultraviolet Spectrophotometric Determination of Rebamipide in Pharmaceutical Products

“…Many UV spectrophotometric methods are reported for other drugs in literature. [8][9][10][11][12][13][14][15][16][17][18][19]…”