Spectrophotometric determination of some anti-tussive and anti-spasmodic drugs through ion-pair complex formation with thiocyanate and cobalt(II) or molybdenum(V)

El-Shiekh, Ragaa; Zahran, Faten; Gouda, Ayman A.

doi:10.1016/j.saa.2006.05.031

Cited by 21 publications

(15 citation statements)

References 28 publications

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“…Above 80 o C is not preferable due to precipitation of the product on walls of tubes [67]. The color remains stable for up to 2-3 hours for both drugs.…”

Section: Effect Of Temperature and Timementioning

confidence: 98%

Application of 4-chloro-7-nitrobenzofurazan for the analysis of propafenone and diltiazem hydrochlorides using kinetic spectrophotometric and spectrofluorimetric methods

et al. 2013

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KEYWORDSSeveral simple, sensitive, accurate and inexpensive spectrophotometric and spectrofluorimetric methods were developed for the determination of propafenone HCl and diltiazem HCl using 4-chloro-7-nitrobenzofurazan (NBD-Cl) accompanied with kinetic study, either in pure form or in pharmaceutical preparations. In this work, the cited drugs react with (NBD-Cl) in presence of borate buffer of pH = 7.6 at a fixed time of 30 minutes on thermostated water bath at (75-80 °C). The absorbance was measured using spectrophotometric technique at 489 and 481 nm for propafenone HCl and diltiazem HCl, respectively, or by using spectrofluorimetric technique after dilution at the specific wavelength of excitation and emission.The calibration curves were linear in the range of 4-44, 16-96 µg/mL when using spectrophotometric method, and 0.4-3.6, 1.6-8.8 µg/mL when spectrofluorimetric method was applied for propafenone HCl and diltiazem HCl, respectively. The limit of quantitation and the limit of detection were also calculated. The methods were applied successfully to commercial dosage form and can be further applied for their determination on a large scale in quality control laboratories. The obtained results statistically agreed with those obtained by reference methods. The determination of the studied drugs by the fixed concentration and rate constant methods is feasible with the calibration equations obtained, but the fixed time method proves to be more applicable.Diltiazem HCl Propafenone HCl Spectroflourimetric Spectrophotometric Kinetic determination 4-Chloro-7-nitrobenzofurazan

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“…Above 80 o C is not preferable due to precipitation of the product on walls of tubes [67]. The color remains stable for up to 2-3 hours for both drugs.…”

Section: Effect Of Temperature and Timementioning

confidence: 98%

Application of 4-chloro-7-nitrobenzofurazan for the analysis of propafenone and diltiazem hydrochlorides using kinetic spectrophotometric and spectrofluorimetric methods

et al. 2013

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“…2 Different spectrophotometric methods have been reported for the determination of DXM in both the bulk drug and the dosage forms. [3][4][5][6][7][8][9][10] The first and second-derivative technique UV spectrophotometry, [11][12][13] thin-layer chromatography, New, simple and convenient potentiometric and spectrophotometric methods are described for the determination of dextromethorphan hydrobromide (DXM) in pharmaceutical preparations. The potentiometric technique is based on developing a potentiometric sensor incorporating the dextromethorphan tetrakis(p-chlorophenyl)borate ion-pair complex as an electroactive species in a plasticized PVC matrix membrane with o-nitophenyl octyl ether or dioctyl phthalate.…”

Section: Introductionmentioning

confidence: 99%

New Potentiometric and Spectrophotometric Methods for the Determination of Dextromethorphan in Pharmaceutical Preparations

Elmosallamy

Amin

2014

ANAL. SCI.

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“…A l i t e r a t u r e r e v i e w s h o w e d t h a t s e v e r a l analytical methods, including high-performance liquid chromatography (HPLC) coupled with UV (Carlucci et al, 2000;Erk, 2001;Ozkan, 2001;Hertzog et al, 2002;Ansari et al, 2004;Bonfilio et al, 2009) or fluorescence (Ritter, Furtek, Lo, 1997) detection, UV and derivative spectrophotometry methods (Prabhakar, Giridhar, 2002;Lastra et al, 2003;Sankar et al, 2003;El-Shiekh et al, 2011;Rao et al, 2011;Subbarao et al, 2012), and reversed-phase high-performance thin-layer chromatography (HPTLC) (McCarthy et al, 1998), have been published for the analysis of PL in pharmaceuticals.…”

Section: Introductionmentioning

confidence: 99%

Optimization of a spectrofluorimetric method based on a central composite design for the determination of potassium losartan in pharmaceutical products

Demirkaya-Miloglu

Yaman

Kadıoğlu

2014

Braz. J. Pharm. Sci.

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Here, a spectrofluorimetric method for the determination of potassium losartan (PL) in pharmaceutical products is described. The effects of critical parameters, pH, acid molarity, and temperature, on the fluorescence intensity of PL were analyzed, and these parameters were optimized using a central composite design (CCD). The highest fluorescent intensity at excitation (λex) and emission (λem) wavelengths of 248 nm and 410 nm, respectively, was achieved using 0.01 M sulfurous acid (pH 2) at 21.6 °C. Under optimum conditions, the method was linear from 0.025-0.5 µg/mL, with a reasonably high correlation coefficient (0.9993). Furthermore, the method was very sensitive (LOQ, 0.006), accurate (RE, ≤7.06), and precise (%RSD, ≤6.51). After development and validation of the method, samples containing PL were analyzed with this method, and the obtained data were statistically compared with those obtained with a previously published reference method using a two one-sided equivalence test (TOST). According to the data, the results from the proposed and reference assays were equivalent. Descreve-se método espectrofluorométrico para a determinação de losartana potássica (PL) em produtos farmacêuticos. Os efeitos de parâmetros críticos (pH, molaridade ácida e temperatura) na intensidade da fluorecência foram otimizados usando o planejamento de componente central (DCC). A mais alta intensidade fluorescente com λex=248 nm e λem= 410 nm foi obtida usando ácido sulfúrico 0.01 M (pH 2) e 21.6 ºC. Nas condições ideais, a linearidade do método foi estabelecida na faixa de concentração de 0.025-0.5 µg/mL com coeficiente de correlação bastante elevado (0.9993). Além disso, o método foi muito sensível com valor de LOQ 0.006, exato (RE≤7.06) e preciso (RSD%≤6.51). Depois do desenvolvimento e validação do método, amostras de medicamentos contendo PL foram analisadas com este método e os resultados obtidos foram comparados estatisticamente com método de referência, publicado anteriormente, usando o Teste de equivalência TOST (Teste de Equivalência Unilateral). De acordo com os dados estatísticos, os resultados do ensaio de referência e do método proposto foram equivalentes.Uniterms: Losartana potássica/planejamento de componente central. Espectrofluorimetria/análise quantitativa. Formulações farmacêuticas/análise quantitativa.

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Spectrophotometric determination of some anti-tussive and anti-spasmodic drugs through ion-pair complex formation with thiocyanate and cobalt(II) or molybdenum(V)

Cited by 21 publications

References 28 publications

Application of 4-chloro-7-nitrobenzofurazan for the analysis of propafenone and diltiazem hydrochlorides using kinetic spectrophotometric and spectrofluorimetric methods

Application of 4-chloro-7-nitrobenzofurazan for the analysis of propafenone and diltiazem hydrochlorides using kinetic spectrophotometric and spectrofluorimetric methods

New Potentiometric and Spectrophotometric Methods for the Determination of Dextromethorphan in Pharmaceutical Preparations

Optimization of a spectrofluorimetric method based on a central composite design for the determination of potassium losartan in pharmaceutical products

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