Spectrophotometric determination of sulphacetamide sodium via diazotization and coupling reaction

Al-Safar, Rana S.; Othman, Nabeel S.

doi:10.1088/1757-899x/928/5/052017

Cited by 3 publications

(3 citation statements)

References 16 publications

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“…By applying the following mathematical relationships [25], the value of the detection limit (LOD) and the value of the quantitative estimate limit (LOQ) are cal- It is known that the absorption intensity at 597 nm is linearly related to the RB5 concentration of solutions. To evaluate the dye reduction rate, calibration curves [22,23], with absorbance as a function of the concentration of dye patterns, were previously prepared (Figure 4b). The linear relationships between 1 to 200 mg•L −1 with good value of determination coefficient (R 2 = 0.9982), were observed.…”

Section: Decolorization Of Rb5 Aqueous Solution By Using Nanocrystall...mentioning

confidence: 99%

Removal of Reactive Black 5 Azo Dye from Aqueous Solutions by a Combination of Reduction and Natural Adsorbents Processes

Mbarek

Daza

Escoda

et al. 2023

Metals

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In this study, a combined process of reduction and adsorption for the degradation of azo dye with nanocrystalline Fe80Si10B10 powder as a reducing agent is analyzed. A mechanical alloying technique produced the powdered alloys needed for the redox process. The synthesized nanocrystalline structure favors the efficiency of the reduction step of Reactive Black 5 (RB5) azo dye. According to the UV-Vis analysis, the reductive process alone allowed for nearly complete color removal after 3 min of reaction. In this regard, the nanocrystallized FeSiB powder has excellent application potential in the first step of the reduction processes for degrading azo dye solutions. Indeed, the nanocrystalline FeSiB powder outperforms commercial Fe powders in terms of degradation efficiency because of the formation of multiple micro-batteries between the α-Fe solid solution and the Fe3Si nanocrystalline phases, favoring the loss of electrons from iron and exhibiting different corrosion resistance. In the second step, the adsorption process, the efficient removal of intermediate undesired compounds from the reduction processes, principally aromatic amines, is analyzed. Different adsorbents, including wood, graphene oxide, activated carbon, and pine particles, were used. The results suggest that graphene oxide and activate carbon performed the best for secondary product adsorption following RB5 degradation. The current study could serve as a guide for environmental applications, such as industrial wastewater treatment, using metallic powders produced by high-energy mechanical alloying.

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Section: Decolorization Of Rb5 Aqueous Solution By Using Nanocrystall...mentioning

confidence: 99%

Removal of Reactive Black 5 Azo Dye from Aqueous Solutions by a Combination of Reduction and Natural Adsorbents Processes

Mbarek

Daza

Escoda

et al. 2023

Metals

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“…It was a white or yellowish crystalline powder, soluble in water, dissolved in an amount of ethanol, insoluble in ether, and has a melting point of 257 °C [3]. SCS had the molecular formula C 8 H 9 N 2 O 3 NaS•H 2 O, and the molecular weight was 254.2 g mol −1 [4]. The chemical structure of the sulfacetamide sodium is shown in Fig.…”

Section: ■ Introductionmentioning

confidence: 99%

Spectrophotometric Determination of Sodium Sulfacetamide Using Pyrocatechol as an Oxidative Coupling Agent

Ali,

Humeidy

2024

Indones. J. Chem.

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Oxidative coupling reaction is one of the simplest and fastest spectrophotometric methods for measuring sodium sulfacetamide (SCS) in pure formulations and pharmaceutical formulations (eye ointment) when compared to other methods that require difficult and costly operating conditions. Here, a new approach for quantifying SCS drug spectrophotometrically by oxidative coupling was described. The research is based on the oxidation of the drug with potassium periodate and then conjugation with pyrocatechol reagent in the neutral medium, which results in a water-soluble and stable reddish-brown product that had an absorption band at 500.5 nm. In this work, oxidant agent quantity, coupling reagent quantity, oxidation time, temperature effect, stoichiometry between SCS and pyrocatechol, interference effect, and calibration curve were all studied. Beer's law linearity ranged from 6.25–112.5 µg mL−1. The molar absorptivity, Sandell’s index, detection limit, determination coefficient, and average recovery percentage were 5185.7 L mol−1 cm−1, 0.049 μg cm−2, 0.0889 µg mL−1, 0.9988, and 100.34% respectively. The determination of sulfacetamide in pharmaceutical preparation eye, ointment was successful using this method.

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“…SAS is white,crystalline powder freely soluble in water slightly soluble in ethanol, sparingly soluble in acetone and partially soluble in ether and chloroform [10]. The scientific name for the sulphacetamide is: N-[(4 − aminophenyl)sulfonyl ]acetamidemonosodium salt monohydrate and the molecular structure is (C8H9N2NaO3S,H2O) [11], and its chemical structure as following [12] :…”

Section: Introductionmentioning

confidence: 99%

Spectrophotometric Determination of Sulphacetamide Sodium Using 2,4-Dinitrophenylhydrazine as Coupling Reagent

Abdulrazzaq¹,

Sultan²

2023

CBERJ

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A Sensitive, rapid and selective spectrophotometric method was developed for the determination of sulfacetamide sodium in an aqueous solution. The method is based on the oxidative coupling reaction with 2,4-dinitophenylhydrazine in the basic medium in the presence of potassium periodate to produce an intense orange colour product, soluble in water, stable and gives maximum absorbance at 484 nm. The linearity of Beer's law was in the range of 2.5-75 μg/ml of sulfacetamide. The molar absorptivity, Sandellʼs sensitivity, and detection limit were 3202.92 L/mol.cm, 0.07936 µg/cm2 and 0.50476 μg/ml respectively. This method is applied successfully to the determination of sulfacetamide in pharmaceutical preparation (eye drops and ointment).

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Spectrophotometric determination of sulphacetamide sodium via diazotization and coupling reaction

Cited by 3 publications

References 16 publications

Removal of Reactive Black 5 Azo Dye from Aqueous Solutions by a Combination of Reduction and Natural Adsorbents Processes

Removal of Reactive Black 5 Azo Dye from Aqueous Solutions by a Combination of Reduction and Natural Adsorbents Processes

Spectrophotometric Determination of Sodium Sulfacetamide Using Pyrocatechol as an Oxidative Coupling Agent

Spectrophotometric Determination of Sulphacetamide Sodium Using 2,4-Dinitrophenylhydrazine as Coupling Reagent

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