Spectrophotometric Determination of Valacyclovir in Pharmaceutical Formulations

Abstract

A simple spectrophotometric method has been developed for the estimation of valacyclovir in pharmaceutical preparations. The method is based on the reaction of the valacyclovir with methanolic solution of para dimethyl amino benzaldehyde (PDAB) in acidic condition producing Schiff base having absorption maximum at 400 nm. Beer's law is obeyed in the concentration of 50-250 µg/mL of valacyclovir. Statistical analysis proves that the proposed method is reproducible and selective for the estimation of valacyclovir in bulk drug and in its tablet dosage form.

Telmisartan

“…Srihari et al [53] developed two simple, sensitive, and economical spectrophotometric methods for the estimation of telmisartan in pharmaceutical dosage forms. A method was based on the formation of chloroform extractable complex of telmisartan with a wool fast blue.…”

Colorimetric Quantitative Estimation of Abacavir Sulphate in Pharmaceutical Dosage Form

“…It is a nucleoside reverse transcriptase inhibitor with antiretroviral activity against HIV. Review of literature reveals that the drug is estimated by using High Performance Liquid Chromatography [2][3][4][5] and UV-VIS spectroscopy [6][7][8][9][10][11]. The present research describes two simple methods for visible spectrophotometric estimation of Abacavir Sulphate from its tablet Formulation.…”

Isolation and identification of a potential unknown impurity in montelukast drug substance resulting from photolytic degradation

“…Impurity proling and metabolic study of montelukast was reported using mass spectrometric techniques. 12,14 Montelukast sodium is a US pharmacopeia listed drug substance for which six impurities are reported. 13 The impurity identied in the present work is different from the reported impurities.…”