A simple spectrophotometric method has been developed for the estimation of valacyclovir in pharmaceutical preparations. The method is based on the reaction of the valacyclovir with methanolic solution of para dimethyl amino benzaldehyde (PDAB) in acidic condition producing Schiff base having absorption maximum at 400 nm. Beer's law is obeyed in the concentration of 50-250 µg/mL of valacyclovir. Statistical analysis proves that the proposed method is reproducible and selective for the estimation of valacyclovir in bulk drug and in its tablet dosage form.

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A simple spectrophotometric method for determination of famotidine was described. The method was based on bromination of the drug with excess brominating mixture in acidic medium. The yellow colour developed was measured at 350 nm against distilled water blank. Beer's law was obeyed in the range of 40-200 µg/ml. 2-aminoiminomethyl)amino-]4 thiazolyl]methyl]thio]-N-(aminosulfonyl) propaninidamide, is used in the treatment of duodenal ulcer, gastric ulcer, stress ulcers and gastritis. Various methods have been reported for estimation of famotidine, which include spectrophotometric methods 1-3 , spectrophotometric and *For correspondence E-mail: ramireddy_m2000@yahoo.co.in spectrofluorimetric method 4 and flow-injection analysis 5 . Famotidine, chemically 3-[[[(In the present communication, a simple spectrophotometric method has been developed for the estimation of famotidine from pharmaceutical preparations. The proposed method was based on the bromination of the drug with excess brominating mixture in acidic medium. After bromination, the excess brominating mixture was treated with potassium iodide, which gave yellow colour. The maximum absorbance was measured at 350 nm. The

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