Spectrophotometric Simultaneous Analysis of Analgin – Adamon Mixture in Injection Preparations

Acar, Nevin; Onur, Feyyaz

doi:10.1080/00032719608001782

Cited by 10 publications

(1 citation statement)

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“…2,3 Various methods have been established for the quantitative determination of novalgin in pharmaceutical formulations including titrimetry in aqueous 4,5 and non-aqueous 6 media, HPLC with UV detection, 7-9 voltammetry, 10 polarography 11 and spectrophotometry. [12][13][14][15][16][17][18] Nowadays, more strict regulation related to the quality control of pharmaceuticals has led to increasing demands for the automation of the analytical assays carried out in appropriate control laboratories. Flow injection analysis (FIA) is a versatile instrumental tool due to its simplicity, small sample volumes, low reagent consumption, and high reproducibility; such analysis generally allows the acquisition of a great number of analytical data at low cost and in a relatively short analysis time.…”

Section: Introductionmentioning

confidence: 99%

Flow-Injection Spectrophotometric Determination of Novalgin in Pharmaceuticals Using Micellar Medium

et al. 2007

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A sensitive flow-injection (FI) procedure with spectrophotometric detection in a micellar medium is proposed for the determination of novalgin. The method is based on the instantaneous formation of a red-orange product (λmax = 510 nm) after the reaction between novalgin and p-dimethylaminocinnamaldehyde (p-DAC) in a dilute acid medium. The sensitivity of this reaction was increased by a factor of 5.6 in the presence of sodium dodecyl sulfate (SDS). Experimental design methodologies were used to optimize the chemical and FI variables. The calibration curve was linear in the range of 1.45 × 10 -6 to 2.90 × 10 -5 mol L -1 with an excellent correlation coefficient (r = 0.9999). The detection limit was 1.31 × 10 -7 mol L -1 (n = 20, RSD = 2.0%). No interferences were observed from the common excipients. The results obtained by the proposed method were favorably compared with those given by the iodometric reference method at 95% confidence level.

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