Spectroscopic and molecular docking studies for the binding and interaction aspects of curcumin-cysteine conjugate and rosmarinic acid with human telomeric G-quadruplex DNA

Cobalt(ii)–curcumin cysteine conjugate as c-MYC promoter G-quadruplex selective switch-on fluorescence probe

“…Two distinct peaks can be seen at binding energies of 781.00 eV and 793.24 eV for Co 2p3/2 and Co 2p1/2, respectively, showing that Co ions are primarily in the +2 state. 19 The peak at 781.00 eV is associated with Co–O binding as reported previously. 23…”

“…Two distinct peaks can be seen at binding energies of 781.00 eV and 793.24 eV for Co 2p3/2 and Co 2p1/2, respectively, showing that Co ions are primarily in the +2 state. 19 The peak at 781.00 eV is associated with Co-O binding as reported previously. 23 To further characterize the morphology and structural features of the Co-CC conjugate, scanning electron microscopy (SEM), transmission electron microscopy (TEM) and selected area electron diffraction (SAED) studies were performed.…”

“…Curcumin cysteine was synthesized according to a previous report. 19 Further, the fluorescent nanosensing probe based on the cobalt–curcumin cysteine ( Co–CC ) conjugate was prepared as follows: 475.8 mg of CoCl 2 ·6H 2 O (0.4 M) was mixed with 0.26 mg of citric acid (0.25 mM). Following a 10 min sonication of the reaction mixture, 76 mg of sodium borohydride (0.1 M) dissolved in 200 ml of deionized water was added dropwise.…”

Structural insights and shedding light on preferential interactions of dietary flavonoids with G-quadruplex DNA structures: A new horizon

“…Curcumin comprises 2 aromatic ring configurations with o-methoxy phenolic groups which are linked by a 7-carbon coupler made up of an alpha, beta-unsaturated beta-diketone molecule. Curcumin has an effective electron transfer capacity owing to its unusual structure and many functional units, which include a beta-diketone and multiple π-electrons capable of conjugating between 2 phenyl rings [ 67 , 68 ]. Curcumin has previously been discovered to interact with the telomeric G-quadruplex during molecular crowding conditions.…”

Mechanistic aspects of binding of telomeric over parallel G‐quadruplex with novel synthesized Knoevenagel condensate 4‐nitrobenzylidene curcumin

“…We have earlier reported that the curcumin and its many synthesized analogue as potential G-quadruplex binders and its role in the apoptosis of cancer cell lines. 19,25 Here, we are here reporting synthesis of the new analogue of curcumin, that is 4-nitrobenzylidene curcumin (NBC) obtained through the Knoevenagel condensation reaction of the curcumin. The conjugation connection between the phenolic and enolic hydroxyls is crucial for the ability to scavenge free radicals.…”