Spectroscopic characterization of in vitro interactions of cetirizine and NSAIDS

Abstract

Background: Cetirizine (anti-allergy agent) and non-steroidal anti-inflammatory drugs (NSAIDs; anti-inflammatory agents) are co-administered drugs. Cetirizine, a P-glycopretein substrate may be affected by the use of NSAIDs. In the present work, quantification of cetirizine in the presence of commonly co-administered NSAIDs such as diclofenac sodium, ibuprofen, flurbiprofen, tiaprofenac acid, meloxicam and mefenamic acid were studied using the RP-HPLC technique. Methods: A high-throughput HPLC method for the analysis of cetirizine was developed, validated in the presence of NSAIDs and was further used to study the interactions of cetirizine in the presence of NSAIDs at four different pH levels. Purospher Star, C18 column (5 μm, 25 cm × 0.46 cm) with a mobile phase of methanol/water (90:10 v/v, pH adjusted to 3.5) at a flow rate of 1.0 mL/min and a wavelength of 240 nm was used.

Levocetirizine Dihydrochloride-Loaded Chitosan Nanoparticles: Formulation and <i>In Vitro</i> Evaluation

“…A very weak singlet was present at 10.6 ppm for the one proton of the carboxylic acid group. 33 Some characteristic peaks of LCD were found also in the spectra of nanoparticle formulations, indicating successful incorporation of drug into the nanoparticles with no chemical changes. 34 The data were also supported by the DSC and FT-IR results.…”

HPLC method development, validation and its application to investigate in vitro effect of pioglitazone on the availability of H1 receptor antagonists

“…Reported methods were utilized for interaction (Arayne et al, 2008(Arayne et al, , 2010cMirza et al, 2013a;Shamshad et al, 2014). Briefly, in each set of experiment, pioglitazone tablet was added into the dissolution medium along with fexofenadine, cetirizine or levocetirizine tablets at zero minute.…”

“…In vitro techniques offer a complete means to create a huge amount of data using minimum resources. Investigation of in vitro drug interactions has also been reported by using minimum standards (Arayne et al, 2008(Arayne et al, , 2010cMirza et al, 2013b;Shamshad et al, 2014). These suggested that in vitro approaches should be properly characterized; validated and proper controls should be incorporated in routine use.…”

Application of RP-HPLC method for the simultaneous determination of cetirizine in the presence of quinolones

“…Similarly, the number of HPLC methods has been reported for the determination of cetirizine in the presence of several other drugs as pseudoephedrine [16], chloroquine and pyrimethamine [17], hydroxyzine [18], H 2 receptor antagonists [19], statins [20], with different antihistamine [21], calcium-channel blockers [22], and NSAIDs [23]. However, no method for the simultaneous determination of cetirizine in the presence of quinolones was reported.…”