Spectroscopic investigations and crystal structure from synchrotron powder data of the inclusion complex of β-cyclodextrin with atenolol

Borodi, Gheorghe; Bratu, Ioan; Dragan, Felicia; Peschar, R.; Helmholdt, Robert B.; Hernanz, A.

doi:10.1016/j.saa.2007.10.021

Cited by 19 publications

(11 citation statements)

References 19 publications

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“…The value of the association constant also correlates to that obtained by us ( Fig. 16) and by Borodi et al (Borodi et al, 2008) (110±22 M -1 , Scott's model) from UV-vis absorption data. As stated above, molecular mechanics calculations were performed using the MM+ force field in order to gain theoretical support for two experimental results: www.intechopen.com a. the negative signal of the dichroic band of atenolol in the 1:1 complex.…”

Section: Characterization Of the Atenolol-cyclodextrin Inclusion Compsupporting

confidence: 89%

“…have been employed for the characterization of the CD inclusion complexes of atenolol in solid state (Borodi et al, 2008;Ficarra et al, 2000aFicarra et al, , 2000b. In the following, we will present our results on the interaction of atenolol with -, -and -CD in solution, studied by means of fluorescence, circular dichroism and absorption spectroscopies.…”

Section: Characterization Of the Atenolol-cyclodextrin Inclusion Compmentioning

confidence: 99%

See 1 more Smart Citation

The Determination of the Stoichiometry of Cyclodextrin Inclusion Complexes by Spectral Methods: Possibilities and Limitations

Tablet¹,

Matei²,

Hillebrand³

2012

Stoichiometry and Research - The Importance of Quantity in Biomedicine

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Section: Characterization Of the Atenolol-cyclodextrin Inclusion Compsupporting

confidence: 89%

Section: Characterization Of the Atenolol-cyclodextrin Inclusion Compmentioning

confidence: 99%

The Determination of the Stoichiometry of Cyclodextrin Inclusion Complexes by Spectral Methods: Possibilities and Limitations

Tablet¹,

Matei²,

Hillebrand³

2012

Stoichiometry and Research - The Importance of Quantity in Biomedicine

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“…Theoretical calculation, associated with classical characterization techniques, such as NMR, IR, Raman, VCD, UV-vis, thermal analysis, and so on, can play a crucial role to clarify fundamental aspects concerning the chemistry of CDs complex formation [15][16][17][18][19][20][21][22]. The size and conformal flexibility of CDs make the geometrical optimization very expensive and difficult precluding the use of more sophisticated ab initio methods, such as Møller-Plesset perturbation theory (MP2, MP3 or MP4).…”

Section: Introductionmentioning

confidence: 99%

Host–guest complex of cypermethrin with β-cyclodextrin: A spectroscopy and theoretical investigation

Wei

Bi-tai

Chen

et al. 2011

Journal of Molecular Structure

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“…Siklodekstrin memiliki ke unggulan yaitu dapat membentuk kompleks inklusi dengan berbagai senyawa lainnya dengan cara bagian dalam rongganya berinteraksi dengan molekul senyawa obat (guest), lalu sifat fisika dan kimia dari guest akan berubah. Interaksi tersebut akan meningkatkan kelarutan, laju disolusi, bioavailabilitas, dan stabilitas obat [4]. Metode solvent evaporation merupakan metode yang cukup sederhana dan relatif ekonomis baik untuk skala laboratorium maupun untuk produksi skala besar, serta dapat menjadi alternatif pengggunaan teknik spray drying [5].…”

Section: Pendahuluanunclassified

Pengaruh Co-Process Superdisintegran Crospovidone- Croscarmellose Sodium (1:3) pada Sediaan Orally Disintegrating Tablet Atenolol-β-Siklodekstrin

Parfati

Rani

Saputra

2018

MPI

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ABSTRAK:Orally Disintegrating Tablet (ODT) merupakan bentuk sediaan yang dikembangkan untuk mempercepat waktu hancur, meningkatkan kepatuhan pasien dan efek terapi obat. ODT dirancang memiliki sifat mudah hancur pada rongga mulut kurang dari 1 menit, sehingga geriatri tidak memerlukan tambahan air untuk membantu menelan dan cocok untuk penderita geriatri. Pada penelitian ini dilakukan formulasi sediaan ODT dengan pembentukan kompleks inklusi atenolol-β-siklodekstrin dengan penambahan superdisintegran co-process crospovidone-croscarmellose sodium (1:3) menggunakan metode cetak langsung. Evaluasi pembuatan ODT terdiri dari uji pre-kompresi dan postkompresi. Hasil pembuatan ODT atenolol-β-siklodekstrin juga diuji statistik dari segi waktu pembasahan, rasio penyerapan air, waktu hancur, waktu dispersi in vitro, dan parameter disolusi (AUC, %ED, dan Kr). Penambahan co-process superdisintegran menunjukkan waktu pembasahan 44,45 ± 2,76 detik; rasio penyerapan air 26,27 ± 1,1%; waktu hancur 38,07 ± 4,56 detik; dan waktu dispersi in vitro 73,83 ± 2,71 detik. Hasil Uji disolusi didapatkan nilai AUC 3983,40 ± 189,60; ED 66,39 ± 3,16%; dan Kr 0,0778 ± 0,04. Campuran fisik menunjukkan waktu pembasahan 44,87 ± 3,33 detik; rasio penyerapan air 27,76 ± 1,35%; waktu hancur 38,28 ± 5,32 detik; dan waktu dispersi in vitro 83,20 ± 2,67 detik. Hasil uji disolusi didapatkan nilai AUC 3916,20 ± 235,80; ED 65,27 ± 3,93%; dan Kr 0,0655 ± 0,03. Berdasarkan hasil penelitian yang diperoleh, dapat dilihat bahwa penambahan superdisintegran co-process menunjukkan hasil yang tidak berbeda bermakna dengan campuran fisik.Kata kunci: atenolol; β-siklodekstrin; orally disintegrating tablet; co-process; crospovidone-croscarmellose sodium revealed AUC 3983.40 ± 189.60; ED 66.39 ± 3.16%; and Cr 0.0778 ± 0.04 ABSTRACT: Orally Disintegrating Tablet (ODT) is a dosage form that was developed to improve the quality of therapy and patient's compliance. Orally disintegrating tablet can disintegrate easily in the oral cavity in less than 1 minute, so it does not require water to help swallow. In this research, ODT was formulated using inclusion complexes of atenolol-β-cyclodextrin and the addition of co-process superdisintegrant crospovidone-croscarmellose sodium (1:3). The tablet was prepared by direct compression method. The evaluation of ODT consists of pre-compression and post-compression tests. The results also were tested statistically in terms of wetting time, water absorption ratio, disintegration time, in vitro dispersion time and dissolution parameters (AUC, %ED, and Cr

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Spectroscopic investigations and crystal structure from synchrotron powder data of the inclusion complex of β-cyclodextrin with atenolol

Cited by 19 publications

References 19 publications

The Determination of the Stoichiometry of Cyclodextrin Inclusion Complexes by Spectral Methods: Possibilities and Limitations

The Determination of the Stoichiometry of Cyclodextrin Inclusion Complexes by Spectral Methods: Possibilities and Limitations

Host–guest complex of cypermethrin with β-cyclodextrin: A spectroscopy and theoretical investigation

Pengaruh Co-Process Superdisintegran Crospovidone- Croscarmellose Sodium (1:3) pada Sediaan Orally Disintegrating Tablet Atenolol-β-Siklodekstrin

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