Spectroscopic studies of water-soluble sulfonated calix[6]arene

Aqueous solubilization of furosemide by supramolecular complexation with 4-sulphonic calix[n]arenes

“…The HPLC method used in this study complied with specifications for precision, accuracy, selectivity, linearity, and ruggedness as required by the USP XXIV (USP 2000). Analysis was carried out with an automated highperformance liquid chromatograph (AS1000 autosampler (1992), Zhang et al (1996). and P2000 pump, Thermo Separation Products, Waltham, MA) with a UV detector (UV3000 detector) set at 276 nm.…”

“…In addition, the ease with which various functional groups can be introduced to modify either the upper or the lower rim of the 'cup' makes it easy to change the affinity of these cyclooligomers towards target molecules and/or increase the solubility of the calixarenes (Shinkai 1986;Shinkai et al 1986Shinkai et al , 1988. One such modified calixarene, the water-soluble 4-sulphonic calix[n]arenes, may selectively include various guests according to their size and hydrophobicity in a manner similar to cyclodextrins (Szejtli 1982;Shuette et al 1992;Zhang et al 1996).…”

Transportation of Poorly Soluble Drug Molecules from the Organic Phase to the Aqueous Phase by Using Phosphorylated Calixarenes

“…To overcome these limitations water-soluble groups containing positive or negative charges such as amine, phosphonate, and sulfonate groups or neutral groups such as sulfonamide, sugar, and polyoxyethylene but highly hydrophilic groups can be located on the lower or upper rim of calixarene skeleton. Calixarenes may selectively include various guests according to their size and hydrophobicity in a manner similar to cyclodextrins. − Although the Foor and Drug Administration (FDA) has currently not approved the use of calixarenes in medicines to date, the calixarenes have showed neither toxicity nor immune response . This situation increases interest in their use in the biopharmaceutical applications beyond their current use for the chiral separation of molecules and as complex forming agents to remove molecules from the environment. − To date, although several works about the effect of the water-soluble p -sulfonic calix[ n ]arenes on the solubility of drugs have been reported, − there is no other published extraction study between poorly soluble drug molecules and water-soluble p -phosphonate calix[ n ]arene receptors.…”

Time-Resolved ESR Study on Complex Radical Pairs Formed in the Photolysis of Methylene Blue Included in Water-Soluble Sulfonated Calixarenes

“…Host molecules of inclusion compounds such as cyclodextrines (CDs) and calixarenes are attractive to many different fields because of their specific properties of formation of host-guest complexes . [1][2][3][4][5][6] These specific inclusion properties can be used for the purpose of molecular identification and separation. The host-guest interaction in the complex is also known as a simplified model of biological enzymes.…”