Spectroscopy, Thermodynamics and Molecular Docking of Fraxinellone with DNA

Ji, Lei; Gou, Xing‐Xing; Sang, Wei; Zhou, Jinhong; Li, Zongxiao

doi:10.1007/s00128-020-02860-7

Cited by 8 publications

(5 citation statements)

References 29 publications

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“…Recently, study of the interactions between three kinds of DNA (armyworm, salmon sperm and calf thymus) and natural product 24 showed only weak interaction. This theoretical study supports the possible application of this compound as a pesticide (Lei et al 2020). Studies have also been conducted to determine antifeedant and larvicidal effects against four major pests, Mythimna separata, Agrotis ypsilon, Plutella xylostella and Culex pipiens pallens.…”

Section: Spodoptera Liturasupporting

confidence: 66%

“…Nimolactones 46-47 were isolated from the same plant and share many similarities with 44-45 but differ in the presence of an unsaturated c-butyrolactone (Siddiqui et al 1992;Kraus et al 1994;Tariq et al 2004;Akihisa et al 2009;Kikuchi et al 2011). Chuktabrin L (48) is the first example of a C16 degraded and C21-C15 cyclized 16-nor-phragmalin-type limonid which was isolated from the stems of Chukrasia tabularis A. Juss Liu et al (2002Liu et al ( , 2008Liu et al ( , 2009, Wang (2006, 2012), Min et al (2010), Lu ¨et al (2010Lu ¨et al ( , 2013, Lu et al (2014), Lv et al (2014Lv et al ( , 2020, Yang et al (2018a), Okuno et al (2019), Lei et al (2020) Neuroprotective activity Yoon et al (2008Yoon et al ( , 2010 2009) (Wang et al 2019a). Cipaferen R (49) was isolated from the twigs and leaves of Cipadessa baccifera.…”

Section: Melazolidesmentioning

confidence: 99%

“…This is exemplified by the Meliaceae and Rutaceae plant families which are sources of many biopesticides including limonoids (Yang and Tang 1988;Akhtar et al 2008;Morgan 2009). From among these active plant metabolites, the insecticidal activity of calodendrolide (1) and fraxinellone (24) has been evaluated in several insect-control studies (Lei et al 2020). The insecticidal activities of degraded limonoids are listed in Table 10.…”

Section: Insect-controlling Activitymentioning

confidence: 99%

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Degraded limonoids: biologically active limonoid fragments re-enhancing interest in Meliaceae and Rutaceae sources

et al. 2023

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Phytochemical studies on the roots, twigs and leaves of Meliaceae and Rutaceae family plants have revealed the presence of non-complex terpenes derived from limonoid fragmentation. The occurrence and chemical structure of these degraded limonoids isolated from 1930 to March 2022 are reported in this review. Particular attention is given to the degradation levels in these compounds and their absolute configuration to discover presumable deconstruction pathways from more complex limonoids. Plausible intermediates have been postulated for most of them that would explain their origin from limonoids. The total or semi-synthesis of the most isolated degraded limonoids or analogues remains undescribed. This review focuses on the bioactivity of these fragmented limonoids and their synthesized analogues. Based on pharmacological and agrochemical studies, degraded limonoids appear to be excellent structural leads to consider for the total or semi-synthesis of more potent derivatives with the aim of discovering new hits and clarifying their modes of action.

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Section: Spodoptera Liturasupporting

confidence: 66%

Section: Melazolidesmentioning

confidence: 99%

Section: Insect-controlling Activitymentioning

confidence: 99%

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Degraded limonoids: biologically active limonoid fragments re-enhancing interest in Meliaceae and Rutaceae sources

et al. 2023

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“…Previous reports have confirmed the anti-inflammatory and neuroprotective effects of FRA in vivo (Hou et al, 2018;Bailly and Vergoten, 2020;Lei et al, 2020). However, there are few studies on the anti-tumor effects of FRA.…”

Section: Discussionmentioning

confidence: 80%

“…Fraxinellone (FRA) is a degradable limonin isolated from the root bark of the Dictamnus plant, which has relatively strong insecticidal activity (Bailly and Vergoten, 2020). In addition, the natural product also has anti-inflammatory and immunomodulatory effects (Lei et al, 2020). Recent studies have shown that it can induce the downregulation of the TGFβ signal transduction pathway to inactivate cancer-related fibroblasts, and cause a decrease in the number of M2 FIGURE 3 | FRA induces autophagy and apoptosis of osteosarcoma cells in vitro.…”

Section: Discussionmentioning

confidence: 99%

Fraxinellone Has Anticancer Activity by Inducing Osteosarcoma Cell Apoptosis via Promoting Excessive Autophagy Flux

Zhang

2021

Front. Pharmacol.

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Osteosarcoma is a malignant bone tumor that is easy to metastasize in the early stage and has a very poor prognosis. Fraxinellone (FRA) is one of the main components isolated from the D. dasycarpus plant. Its anti-inflammatory and neuroprotective effects have been confirmed, but the research on the anti-cancer effect of FRA and its potential mechanism is relatively scarce. In this study, we found that FRA inhibited the proliferation and migration of osteosarcoma cells HOS and MG63 in a dose-dependent manner. Immunofluorescence, fluorescence staining and western blotting analysis showed that FRA could simultaneously induce osteosarcoma cell apoptosis and increase autophagy flux. Subsequent turnaround experiments suggested that the pro-apoptotic effect of FRA was achieved through excessive autophagy flux. The results of the xenograft orthotopic model further supported the anti-cancer effects of FRA, indicating that FRA treatment inhibited the growth of osteosarcoma, and the pro-apoptotic and autophagy effects of FRA were also proved in vivo. These studies provide new ideas for the future treatment of osteosarcoma and offer theoretical support for the anti-cancer mechanism of FRA.

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New insights into the anti-hepatoma mechanism of Alisol G-metal ions complexes based on c-myc DNA

Cai

Cao

et al. 2021

Arabian Journal of Chemistry

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Spectroscopy, Thermodynamics and Molecular Docking of Fraxinellone with DNA

Cited by 8 publications

References 29 publications

Degraded limonoids: biologically active limonoid fragments re-enhancing interest in Meliaceae and Rutaceae sources

Degraded limonoids: biologically active limonoid fragments re-enhancing interest in Meliaceae and Rutaceae sources

Fraxinellone Has Anticancer Activity by Inducing Osteosarcoma Cell Apoptosis via Promoting Excessive Autophagy Flux

New insights into the anti-hepatoma mechanism of Alisol G-metal ions complexes based on c-myc DNA

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