Spectrscopic and Conductometric Analysis of Gabapentin

Abstract

Four simple, sensitive and reproducible methods were developed for the determination of gabapentin (GPT) in pure form and in pharmaceutical preparations. Methods A and B are based on the reaction of cupric chloride with gabapentin to form stable complex, which could be measured spectrophotometrically at λmax246 nm (method A) or by using conductometric technique (method B). While method C and D depends on the formation of ion pair complex between the studied drug and bromothymol blue, bromocresol green respectively this was extractable with methylene chloride. The concentration ranges were 40-95 μg mL-1, 1-15 mg, 100-800 and 10-150 μg mL-1for methods A, B, C and D respectively .The optimization of various experimental conditions were described .The results obtained showed good recoveries, Ringbom optimum concentration ranges were calculated, in addition to molar absorptivity and sandell’s sensitivity, detection and quantification limits. The methods were successfully applied to the determination of GPT in bulk and pharmaceutical preparations. The results were favorably comparable with the official method. The molar combining ratio for methods (A-B) was found to be (2:1) (drug: reagent) while for method (C-D) it was found to be (1:1).

Conductometric determination of sibutramine HCl, sumatriptan succinate and lomefloxacine HCl and the solubility products of their ion associates with molybdophosphoric acid

“…In these cases, the titration curve could be represented by two intersecting lines at the end point. The conductometric technique was used for the determination of many drugs [33,36,39] on using MPA as a titrant; the ion-associates are formed between the studied drugs and MPA as shown in the following equation:…”

Conductometric Determination of Losartan Potassium Using Phosphotungstic Acid, Bromocresol Purple, Mercury (Ii) Chloride, and Cupric Chloride as Reagents

“…The methods determine the cited drug without previous filtration or extraction and therefore avoiding organic solvents using. Precipitimetry conductometric for the determination of different compounds such as captopril [23] and gabapentin [24].…”

Spectroscopic Methods for Quantifying Gabapentin: Framing the Methods without Derivatization and Application to Different Pharmaceutical Formulations

“…Besides ultraviolet visible (UV-Vis) absorption spectroscopy [5][6][7] and fluorescence, 8 other methods have been used for the quantification of GABAp in biological fluids, namely those based on chromatographic techniques [9][10][11][12][13][14] and capillary electrophoresis. 15 The quantification with spectroscopic methods can be made directly or with structural modification by a chemical reaction.…”